Tissue Papers: Leveraging Paper-Based Microfluidics for the Next Generation of 3D Tissue Models

Paper-based scaffolds support the three-dimensional culture of mammalian cells in tissue-like environments. These Tissue Papers, a name that highlights the use of materials obtained from (plant) tissue to generate newly functioning (human) tissue structures, are a promising analytical tool to quanti...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2019-09, Vol.91 (17), p.10916-10926
Main Authors: Cramer, Sabrina M, Larson, Tyler S, Lockett, Matthew R
Format: Article
Language:English
Subjects:
Cell culture
Cellular structure
Chemistry
Mammalian cells
Microfluidics
Plant tissues
Three dimensional models
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Summary:Paper-based scaffolds support the three-dimensional culture of mammalian cells in tissue-like environments. These Tissue Papers, a name that highlights the use of materials obtained from (plant) tissue to generate newly functioning (human) tissue structures, are a promising analytical tool to quantify cellular responses in physiologically relevant extracellular gradients and coculture architectures. Here, we highlight current examples of Tissue Papers, commonly used methods of analysis, and current measurement challenges.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.9b02102