Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases

Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and low-molecular weight isoforms. Numerous studies have demonstrated its insulin-sensitizing, anti-atherogenic, and anti-in...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-02, Vol.21 (4), p.1219
Main Authors: Choi, Hyung Muk, Doss, Hari Madhuri, Kim, Kyoung Soo
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Adiponectin - genetics
Adiponectin - metabolism
Adiponectin - pharmacology
Adipose Tissue, White - metabolism
Animals
Anti-Inflammatory Agents - pharmacology
Arthritis, Rheumatoid - complications
Atherosclerosis - complications
Autoimmune Diseases - complications
Diabetes Mellitus, Type 2 - complications
Disease
Humans
Inflammation - complications
Inflammation - drug therapy
Inflammation - metabolism
Inflammatory Bowel Diseases - complications
Obesity - complications
Protein Isoforms
Renal Insufficiency, Chronic - complications
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and low-molecular weight isoforms. Numerous studies have demonstrated its insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects. Additionally, decreased serum levels of adiponectin is associated with chronic inflammation of metabolic disorders including Type 2 diabetes, obesity, and atherosclerosis. However, recent studies showed that adiponectin could have pro-inflammatory roles in patients with autoimmune diseases. In particular, its high serum level was positively associated with inflammation severity and pathological progression in rheumatoid arthritis, chronic kidney disease, and inflammatory bowel disease. Thus, adiponectin seems to have both pro-inflammatory and anti-inflammatory effects. This indirectly indicates that adiponectin has different physiological roles according to an isoform and effector tissue. Knowledge on the specific functions of isoforms would help develop potential anti-inflammatory therapeutics to target specific adiponectin isoforms against metabolic disorders and autoimmune diseases. This review summarizes the current roles of adiponectin in metabolic disorders and autoimmune diseases.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms21041219