Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-01, Vol.9 (2), p.368
Main Authors: Mazzoldi, Elena Laura, Pastò, Anna, Pilotto, Giorgia, Minuzzo, Sonia, Piga, Ilaria, Palumbo, Pietro, Carella, Massimo, Frezzini, Simona, Nicoletto, Maria Ornella, Amadori, Alberto, Indraccolo, Stefano
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cell culture
Cell division
Clinical medicine
Cytokines
Gene expression
Mutation
Ovarian cancer
Review
Spheroids
Stem cells
Tumors
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Summary:The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9020368