Form from Function, Order from Chaos in Male Germline Chromatin

Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressin...

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Bibliographic Details
Published in:Genes 2020-02, Vol.11 (2), p.210
Main Authors: Ellis, Peter J I, Griffin, Darren K
Format: Article
Language:English
Subjects:
Animals
Chromatin - genetics
DNA Methylation
Histone Code
Humans
Male
Meiosis
Spermatogenesis
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Summary:Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes11020210