Nanosystems for Improved Targeted Therapies in Melanoma

Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative targeted therap...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-01, Vol.9 (2), p.318
Main Authors: Beiu, Cristina, Giurcaneanu, Calin, Grumezescu, Alexandru Mihai, Holban, Alina Maria, Popa, Liliana Gabriela, Mihai, Mara Mădălina
Format: Article
Language:English
Subjects:
Apoptosis
Biocompatibility
Blood vessels
Cancer therapies
Carbon
Chemotherapy
Clinical medicine
Cytotoxicity
Drug delivery systems
Drug resistance
Gold
Immunotherapy
Kinases
Ligands
Lipids
Medical research
Melanoma
Mutation
Nanoparticles
Nanotechnology
Permeability
Proteins
R&D
Regulatory approval
Research & development
Review
Silver
Surface chemistry
Tumors
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Summary:Melanoma is one of the most aggressive forms of skin cancer, with limited therapeutic options. Since its incidence has been rapidly rising in recent years, the study of new targeted therapeutic strategies has increased. The implication of nanoscience in the development of alternative targeted therapies for melanoma has multiple benefits and could significantly improve the outcome of melanoma patients. In this paper, we review the most recent progress in the field of targeted therapies, emphasizing the impact of nanoscale materials on the targeting and controlled release of anti-tumor drugs. The applications of nanomedicine in the management of melanoma are extensive and refer to sentinel lymph node mapping, chemotherapy, and RNA interference; each of these applications harboring the potential to develop efficient and personalized diagnostic techniques and therapies. Further research, especially in clinical trials, is needed to establish whether fighting melanoma on the nanoscale level represents the key to reaching a critical inflection point in mankind's battle with metastatic melanoma.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9020318