Inflammatory Targets in Diabetic Nephropathy

One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies ar...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-02, Vol.9 (2), p.458
Main Authors: Donate-Correa, Javier, Luis-Rodríguez, Desirée, Martín-Núñez, Ernesto, Tagua, Víctor G, Hernández-Carballo, Carolina, Ferri, Carla, Rodríguez-Rodríguez, Ana Elena, Mora-Fernández, Carmen, Navarro-González, Juan F
Format: Article
Language:English
Subjects:
Chemokines
Clinical medicine
Cytokines
Diabetes
Diabetic nephropathy
Immune system
Inflammation
Kidney diseases
Medical prognosis
Metabolism
Oxidative stress
Pathogenesis
Polyamines
Proteins
Review
Tumor necrosis factor-TNF
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Summary:One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies are required to delay the development and the progression of this pathology. This new approach should look beyond the control of traditional risk factors such as hyperglycemia and hypertension. Currently, inflammation has been recognized as one of the underlying processes involved in the development and progression of kidney disease in the diabetic population. Understanding the cascade of signals and mechanisms that trigger this maladaptive immune response, which eventually leads to the development of DN, is crucial. This knowledge will allow the identification of new targets and facilitate the design of innovative therapeutic strategies. In this review, we focus on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discuss the potential utility of new strategies based on agents that target inflammation.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9020458