Temporal association between zolpidem medication and the risk of suicide: A 12-year population-based, retrospective cohort study

There have been concerns about abuse and unnecessary chronic administration of zolpidem, and zolpidem’s relation to suicide risk. To investigate the temporal association of zolpidem with the risk of suicide, we conducted a 12-year, population-based, retrospective cohort study on the National Health...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-03, Vol.10 (1), p.4875, Article 4875
Main Authors: Cho, Chul-Hyun, Jee, Hee-Jung, Nam, Yoon-Ju, An, Hyonggin, Kim, Leen, Lee, Heon-Jeong
Format: Article
Language:English
Subjects:
692/308/174
692/699/476
692/700/155
Abuse
Cohort analysis
Female
Health risk assessment
Humanities and Social Sciences
Humans
Male
multidisciplinary
Odds Ratio
Population studies
Population-based studies
Regression Analysis
Republic of Korea - epidemiology
Retrospective Studies
Risk Factors
Science
Science (multidisciplinary)
Sleep disorders
Sleep Initiation and Maintenance Disorders - drug therapy
Sleep Initiation and Maintenance Disorders - psychology
Suicide
Suicide - statistics & numerical data
Zolpidem
Zolpidem - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There have been concerns about abuse and unnecessary chronic administration of zolpidem, and zolpidem’s relation to suicide risk. To investigate the temporal association of zolpidem with the risk of suicide, we conducted a 12-year, population-based, retrospective cohort study on the National Health Insurance Service–National Sample Cohort (NHIS-NSC), South Korea. Data were collected from 2002 to 2013 from the NHIS-NSC, and data cleaning was performed for 1,125,691 subjects. Cox proportional hazards regression analysis was used to investigate the correlation over time between zolpidem medication and suicide. Over intervals commencing after 80 months of observation, the adjusted hazard ratio of suicides associated with the use of the zolpidem was 2.01 (95% CI: 1.58–2.56; p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-61694-9