LCMV‐specific CD4 T cell dependent polyclonal B‐cell activation upon persistent viral infection is short lived and extrafollicular

Persistent virus infections with non‐ or poorly cytopathic viruses are commonly associated with B cell dysregulations. These include the induction of hypergammaglobulinemia and the emergence of virus‐unspecific antibodies. These seemingly unspecific antibody responses interfere with the virus‐specif...

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Bibliographic Details
Published in:European journal of immunology 2020-03, Vol.50 (3), p.396-403
Main Authors: Greczmiel, Ute, Kräutler, Nike J., Borsa, Mariana, Pedrioli, Alessandro, Bartsch, Ilka, Richter, Kirsten, Agnellini, Paola, Bedenikovic, Gregor, Oxenius, Annette
Format: Article
Language:English
Subjects:
Antibody response
Antigens
Autoantigens
B cells
CD4 antigen
CD4 T cells
Cell activation
chronic infection
Humoral immunity
Hypergammaglobulinemia
Immunity to infection
Immunoglobulin G
Immunoglobulins
Infections
LCMV
Lymphocytes B
Lymphocytes T
Persistent infection
polyclonal B cell activation
Short Communication|Basic
Viral infections
Viruses
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Summary:Persistent virus infections with non‐ or poorly cytopathic viruses are commonly associated with B cell dysregulations. These include the induction of hypergammaglobulinemia and the emergence of virus‐unspecific antibodies. These seemingly unspecific antibody responses interfere with the virus‐specific humoral immunity and contribute to delayed virus control. Whether these virus‐unspecific antibodies are induced in the B cell follicle or at extrafollicular sites and whether one specific CD4 T cell subset is involved in the polyclonal B cell activation is unclear. Here we studied virus‐unrelated IgG antibody responses against self or foreign antigens in the context of persistent lymphocytic choriomeningitis virus (LCMV) infection. We found that the LCMV‐unspecific antibody response is short‐lived and induced predominantly at extrafollicular sites and depends on the presence of LCMV‐specific CD4 T cells. Our data support a scenario in which activated, virus‐specific CD4 T cells provide help to non‐specific B cells at extrafollicular sites, supporting the production of virus unspecific IgG antibodies during persistent viral infection. Chronic LCMV infection induces an LCMV‐unspecific antibody (IgG) response, which is short‐lived, and is induced predominantly at extrafollicular sites. This unspecific IgG response depends on the presence of LCMV‐specific CD4 T cells.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.201948286