The synthetic and therapeutic expedition of isoxazole and its analogs

Isoxazole, constituting an important family of five-membered heterocycles with one oxygen atom and one nitrogen atom at adjacent positions is of immense importance because of its wide spectrum of biological activities and therapeutic potential. It is, therefore, of prime importance that the developm...

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Bibliographic Details
Published in:Medicinal chemistry research 2018, Vol.27 (5), p.1309-1344
Main Authors: Agrawal, Neetu, Mishra, Pradeep
Format: Article
Language:English
Subjects:
Biochemistry
Biological activity
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chemists
Derivatives
Drug development
Flight
Pharmacology/Toxicology
Review Paper
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Summary:Isoxazole, constituting an important family of five-membered heterocycles with one oxygen atom and one nitrogen atom at adjacent positions is of immense importance because of its wide spectrum of biological activities and therapeutic potential. It is, therefore, of prime importance that the development of new synthetic strategies and designing of new isoxazole derivatives should be based on the most recent knowledge emerging from the latest research. This review is an endeavor to highlight the progress in the chemistry and biological activity of isoxazole derivatives which could provide a low-height flying bird’s eye view of isoxazole derivatives to the medicinal chemists for the development of clinically viable drugs using this information.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-018-2152-6