BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)

Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number 1903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitoch...

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Bibliographic Details
Published in:Advanced science 2020-03, Vol.7 (6), p.n/a
Main Authors: Chen, Qiang, Lei, Josh Haipeng, Bao, Jiaolin, Wang, Haitao, Hao, Wenhui, Li, Licen, Peng, Cheng, Masuda, Takaaki, Miao, Kai, Xu, Jun, Xu, Xiaoling, Deng, Chu‐Xia
Format: Article
Language:English
Subjects:
ATM‐AMPK‐DRP1
BRCA1
Frontispiece
inflammasomes
mitochondrial dynamics
mitophagy
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Summary:Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number 1903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitochondria and reactive oxygen species through regulating mitochondrial dynamics, thereby blocking inflammasome activation to prevent mammary tumor metastasis.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202070033