Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia

Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic pain conditions including TN, increased levels of brain-derived neurotrophic factor (BDNF) may enhance pain transmission...

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Bibliographic Details
Published in:Scientific reports 2020-03, Vol.10 (1), p.4998-4998, Article 4998
Main Authors: Liu, Lijuan, He, Lingkun, Yin, Cancan, Huang, Ruoyu, Shen, Wenhao, Ge, Huixiang, Sun, Mengyun, Li, Shujuan, Gao, Yun, Xiong, Wei
Format: Article
Language:English
Subjects:
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Animals
Berberine Alkaloids - pharmacology
Berberine Alkaloids - therapeutic use
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Chronic pain
Disease Models, Animal
Drugs, Chinese Herbal
Extracellular signal-regulated kinase
Ganglion cells
Gene Expression
Humanities and Social Sciences
Immunofluorescence
Immunohistochemistry
Male
MAP Kinase Signaling System - drug effects
multidisciplinary
Neuralgia
Pain
Pain perception
Pain Threshold - drug effects
Phosphorylation
Phosphorylation - drug effects
Phytotherapy
Rats, Sprague-Dawley
Receptor, trkB - genetics
Receptor, trkB - metabolism
Rodents
Science
Science (multidisciplinary)
Surgery
Trigeminal ganglion
Trigeminal Ganglion - metabolism
Trigeminal nerve
Trigeminal Neuralgia - drug therapy
Trigeminal Neuralgia - genetics
Trigeminal Neuralgia - physiopathology
TrkB receptors
Tropomyosin
Western blotting
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Summary:Trigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic pain conditions including TN, increased levels of brain-derived neurotrophic factor (BDNF) may enhance pain transmission. This study compares the effect of palmatine administration on the expression of BDNF and its receptor TrkB (tropomyosin receptor kinase B) in trigeminal ganglion cells of Sprague-Dawley rats in a sham versus TN model group. Within 14 days of surgery, the mechanical allodynia threshold of the TN group was significantly lower than that of the sham group, while the TN + palmatine group had a higher mechanical pain sensitivity threshold than the TN group (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-61969-1