First in‐vivo human imaging at 10.5T: Imaging the body at 447 MHz

Purpose To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. Methods Healthy volunteers were imaged on a 10.5T whole‐body scanner in multiple target anatomies, including the prostate, hip, kidney, liv...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2020-07, Vol.84 (1), p.289-303
Main Authors: He, Xiaoxuan, Ertürk, M. Arcan, Grant, Andrea, Wu, Xiaoping, Lagore, Russell L., DelaBarre, Lance, Eryaman, Yiğitcan, Adriany, Gregor, Auerbach, Eddie J., Moortele, Pierre‐François, Uğurbil, Kâmil, Metzger, Gregory J.
Format: Article
Language:English
Subjects:
10.5T
body imaging
Feasibility
Heart
Hip
Homogeneity
Human performance
Humans
Image acquisition
Image contrast
Image Interpretation, Computer-Assisted
Image quality
Inhomogeneity
Magnetic Resonance Imaging
Male
Management
parallel transmit
Performance evaluation
Prostate
Radio frequency
Radio Waves
Signal-To-Noise Ratio
Torso
ultra‐high field imaging
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Summary:Purpose To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. Methods Healthy volunteers were imaged on a 10.5T whole‐body scanner in multiple target anatomies, including the prostate, hip, kidney, liver, and heart. Phase‐only shimming and spoke pulses were used to demonstrate their performance in managing the B1+ inhomogeneity present at 447 MHz. Imaging protocols included both qualitative and quantitative acquisitions to show the feasibility of imaging with different contrasts. Results High‐quality images were acquired and demonstrated excellent overall contrast and signal‐to‐noise ratio. The experimental results matched well with predictions and suggested good translational capabilities of the RF management strategies previously developed at 7T. Phase‐only shimming provided increased efficiency, but showed pronounced limitations in homogeneity, demonstrating the need for the increased degrees of freedom made possible through single‐ and multispoke RF pulse design. Conclusion The first in‐vivo human imaging was successfully performed at 10.5T using previously developed RF management strategies. Further improvement in RF coils, transmit chain, and full integration of parallel transmit functionality are needed to fully realize the benefits of 10.5T.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.28131