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Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice
Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Le...
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| Published in: | Scientific reports 2020-03, Vol.10 (1), p.5109 |
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| creator | Ren, Zhihua Gu, Xuchu Fang, Jing Cai, Dongjie Zuo, Zhicai Liang, Shuang Cui, Hengmin Deng, Junliang Ma, Xiaoping Geng, Yi Zhang, Ming Xie, Yue Ye, Gang Gou, Liping Hu, Yanchun |
| description | Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS were given phosphate-buffered saline (PBS). Subsequently, spleen histology was analyzed. Then the rates of spleen cell (SC) apoptosis, and expression of the genes and proteins of Bcl-2, Bax, caspase-3 and caspase-9 were quantified in each group at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection. The SC apoptosis rates of the DIO-E. coli groups were lower than those of the DIO-PBS groups at 12, 24 and 72 h (p |
| doi_str_mv | 10.1038/s41598-020-62044-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7083956</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2381625980</sourcerecordid><originalsourceid>FETCH-LOGICAL-g375t-e043619d62e141e52a159d7cf2cf97435ba6252a6edd3ce6e28cc5074a58f4193</originalsourceid><addsrcrecordid>eNpdkUtLxDAUhYMoOozzB1xIwY2baB5Nm2wEGcYHDLjRdcmktzORNKlNK_jvTfHBaDY53HtyOB9B6IySK0q4vI45FUpiwgguGMlzLA7QLAmBGWfscE-foEWMryQdwVRO1TE64YwqyUsyQ-2qacAMWWgy64deex21SzIO1jk92OCn1SqaHfTW7KzOTHA2S2PdhW4I0cbJEDsH4DMDzsX0OqstDNj6ejRQ47CBCFlrDZyio0a7CIvve45e7lbPywe8frp_XN6u8ZaXYsBAcl5QVRcMaE5BMJ1Y69I0zDSqzLnY6IKlaQF1zQ0UwKQxgpS5FrJJhHyObr5yu3HTQm1gQnNV19tW9x9V0Lb6u_F2V23De1USyZUoUsDld0Af3kaIQ9XaONFpD2GMFeOSpgpKkmS9-Gd9DWPvE97kIoQzTmlyne83-q3y8xP8E3-NjS4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2380032311</pqid></control><display><type>article</type><title>Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice</title><source>Full-Text Journals in Chemistry (Open access)</source><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Ren, Zhihua ; Gu, Xuchu ; Fang, Jing ; Cai, Dongjie ; Zuo, Zhicai ; Liang, Shuang ; Cui, Hengmin ; Deng, Junliang ; Ma, Xiaoping ; Geng, Yi ; Zhang, Ming ; Xie, Yue ; Ye, Gang ; Gou, Liping ; Hu, Yanchun</creator><creatorcontrib>Ren, Zhihua ; Gu, Xuchu ; Fang, Jing ; Cai, Dongjie ; Zuo, Zhicai ; Liang, Shuang ; Cui, Hengmin ; Deng, Junliang ; Ma, Xiaoping ; Geng, Yi ; Zhang, Ming ; Xie, Yue ; Ye, Gang ; Gou, Liping ; Hu, Yanchun</creatorcontrib><description>Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS were given phosphate-buffered saline (PBS). Subsequently, spleen histology was analyzed. Then the rates of spleen cell (SC) apoptosis, and expression of the genes and proteins of Bcl-2, Bax, caspase-3 and caspase-9 were quantified in each group at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection. The SC apoptosis rates of the DIO-E. coli groups were lower than those of the DIO-PBS groups at 12, 24 and 72 h (p < 0.05). Anti-apoptotic Bcl-2 expression gene and protein of the DIO-E. coli groups were higher than those of the DIO-PBS groups (p < 0.05). Gene expressions of pro-apoptotic Bax, caspase-3 and caspase-9 of the DIO-E. coli groups were lower than those of DIO-PBS groups at 12, 24 and 72 h (p < 0.05). The SC apoptosis rates of the Lean-E. coli groups were higher than those of the Lean- PBS groups at 12 h and 24 h (p < 0.05). Interestingly, the SC apoptosis rates in the DIO-E. coli groups were lower than those of the Lean-E. coli groups at 12 h (p < 0.05). In conclusion, our results suggested that the DIO mice presented stronger anti-apoptotic abilities than Lean mice in non-fatal acute pneumonia induced by E. coli infection, which is more conducive to protecting the spleen and improving the immune defense ability of the body.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-62044-5</identifier><identifier>PMID: 32198370</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Administration, Intranasal ; Animals ; Apoptosis ; Apoptosis - immunology ; BAX protein ; Bcl-2 protein ; bcl-2-Associated X Protein - biosynthesis ; Caspase 3 - biosynthesis ; Caspase 9 - biosynthesis ; Caspase-3 ; Caspase-9 ; Diet ; E coli ; Escherichia coli ; Escherichia coli - immunology ; Escherichia coli Infections - immunology ; Escherichia coli Infections - microbiology ; Escherichia coli Infections - mortality ; Histology ; Immune response ; Immune system ; Macrophages - immunology ; Male ; Megakaryocytes - immunology ; Mice ; Mice, Obese ; Neutrophils - immunology ; Obesity - immunology ; Pneumonia - immunology ; Pneumonia - microbiology ; Pneumonia - mortality ; Proto-Oncogene Proteins c-bcl-2 - biosynthesis ; Spleen ; Spleen - cytology ; Spleen - immunology</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.5109</ispartof><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2380032311/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2380032311?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32198370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ren, Zhihua</creatorcontrib><creatorcontrib>Gu, Xuchu</creatorcontrib><creatorcontrib>Fang, Jing</creatorcontrib><creatorcontrib>Cai, Dongjie</creatorcontrib><creatorcontrib>Zuo, Zhicai</creatorcontrib><creatorcontrib>Liang, Shuang</creatorcontrib><creatorcontrib>Cui, Hengmin</creatorcontrib><creatorcontrib>Deng, Junliang</creatorcontrib><creatorcontrib>Ma, Xiaoping</creatorcontrib><creatorcontrib>Geng, Yi</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Xie, Yue</creatorcontrib><creatorcontrib>Ye, Gang</creatorcontrib><creatorcontrib>Gou, Liping</creatorcontrib><creatorcontrib>Hu, Yanchun</creatorcontrib><title>Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS were given phosphate-buffered saline (PBS). Subsequently, spleen histology was analyzed. Then the rates of spleen cell (SC) apoptosis, and expression of the genes and proteins of Bcl-2, Bax, caspase-3 and caspase-9 were quantified in each group at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection. The SC apoptosis rates of the DIO-E. coli groups were lower than those of the DIO-PBS groups at 12, 24 and 72 h (p < 0.05). Anti-apoptotic Bcl-2 expression gene and protein of the DIO-E. coli groups were higher than those of the DIO-PBS groups (p < 0.05). Gene expressions of pro-apoptotic Bax, caspase-3 and caspase-9 of the DIO-E. coli groups were lower than those of DIO-PBS groups at 12, 24 and 72 h (p < 0.05). The SC apoptosis rates of the Lean-E. coli groups were higher than those of the Lean- PBS groups at 12 h and 24 h (p < 0.05). Interestingly, the SC apoptosis rates in the DIO-E. coli groups were lower than those of the Lean-E. coli groups at 12 h (p < 0.05). In conclusion, our results suggested that the DIO mice presented stronger anti-apoptotic abilities than Lean mice in non-fatal acute pneumonia induced by E. coli infection, which is more conducive to protecting the spleen and improving the immune defense ability of the body.</description><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - immunology</subject><subject>BAX protein</subject><subject>Bcl-2 protein</subject><subject>bcl-2-Associated X Protein - biosynthesis</subject><subject>Caspase 3 - biosynthesis</subject><subject>Caspase 9 - biosynthesis</subject><subject>Caspase-3</subject><subject>Caspase-9</subject><subject>Diet</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - immunology</subject><subject>Escherichia coli Infections - immunology</subject><subject>Escherichia coli Infections - microbiology</subject><subject>Escherichia coli Infections - mortality</subject><subject>Histology</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>Megakaryocytes - immunology</subject><subject>Mice</subject><subject>Mice, Obese</subject><subject>Neutrophils - immunology</subject><subject>Obesity - immunology</subject><subject>Pneumonia - immunology</subject><subject>Pneumonia - microbiology</subject><subject>Pneumonia - mortality</subject><subject>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkUtLxDAUhYMoOozzB1xIwY2baB5Nm2wEGcYHDLjRdcmktzORNKlNK_jvTfHBaDY53HtyOB9B6IySK0q4vI45FUpiwgguGMlzLA7QLAmBGWfscE-foEWMryQdwVRO1TE64YwqyUsyQ-2qacAMWWgy64deex21SzIO1jk92OCn1SqaHfTW7KzOTHA2S2PdhW4I0cbJEDsH4DMDzsX0OqstDNj6ejRQ47CBCFlrDZyio0a7CIvve45e7lbPywe8frp_XN6u8ZaXYsBAcl5QVRcMaE5BMJ1Y69I0zDSqzLnY6IKlaQF1zQ0UwKQxgpS5FrJJhHyObr5yu3HTQm1gQnNV19tW9x9V0Lb6u_F2V23De1USyZUoUsDld0Af3kaIQ9XaONFpD2GMFeOSpgpKkmS9-Gd9DWPvE97kIoQzTmlyne83-q3y8xP8E3-NjS4</recordid><startdate>20200320</startdate><enddate>20200320</enddate><creator>Ren, Zhihua</creator><creator>Gu, Xuchu</creator><creator>Fang, Jing</creator><creator>Cai, Dongjie</creator><creator>Zuo, Zhicai</creator><creator>Liang, Shuang</creator><creator>Cui, Hengmin</creator><creator>Deng, Junliang</creator><creator>Ma, Xiaoping</creator><creator>Geng, Yi</creator><creator>Zhang, Ming</creator><creator>Xie, Yue</creator><creator>Ye, Gang</creator><creator>Gou, Liping</creator><creator>Hu, Yanchun</creator><general>Nature Publishing Group</general><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200320</creationdate><title>Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice</title><author>Ren, Zhihua ; Gu, Xuchu ; Fang, Jing ; Cai, Dongjie ; Zuo, Zhicai ; Liang, Shuang ; Cui, Hengmin ; Deng, Junliang ; Ma, Xiaoping ; Geng, Yi ; Zhang, Ming ; Xie, Yue ; Ye, Gang ; Gou, Liping ; Hu, Yanchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g375t-e043619d62e141e52a159d7cf2cf97435ba6252a6edd3ce6e28cc5074a58f4193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Intranasal</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ren, Zhihua</au><au>Gu, Xuchu</au><au>Fang, Jing</au><au>Cai, Dongjie</au><au>Zuo, Zhicai</au><au>Liang, Shuang</au><au>Cui, Hengmin</au><au>Deng, Junliang</au><au>Ma, Xiaoping</au><au>Geng, Yi</au><au>Zhang, Ming</au><au>Xie, Yue</au><au>Ye, Gang</au><au>Gou, Liping</au><au>Hu, Yanchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice</atitle><jtitle>Scientific reports</jtitle><addtitle>Sci Rep</addtitle><date>2020-03-20</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>5109</spage><pages>5109-</pages><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Splenic immune function was enhanced in diet-induced-obese (DIO) mice caused by Escherichia coli. The changes in spleen function on apoptosis were still unknown. Two hundred mice in groups Lean-E. coli and DIO-E. coli were intranasal instillation of E. coli. And another two hundred mice in groups Lean-PBS and DIO-PBS were given phosphate-buffered saline (PBS). Subsequently, spleen histology was analyzed. Then the rates of spleen cell (SC) apoptosis, and expression of the genes and proteins of Bcl-2, Bax, caspase-3 and caspase-9 were quantified in each group at 0 h (uninfected), 12 h, 24 h, and 72 h postinfection. The SC apoptosis rates of the DIO-E. coli groups were lower than those of the DIO-PBS groups at 12, 24 and 72 h (p < 0.05). Anti-apoptotic Bcl-2 expression gene and protein of the DIO-E. coli groups were higher than those of the DIO-PBS groups (p < 0.05). Gene expressions of pro-apoptotic Bax, caspase-3 and caspase-9 of the DIO-E. coli groups were lower than those of DIO-PBS groups at 12, 24 and 72 h (p < 0.05). The SC apoptosis rates of the Lean-E. coli groups were higher than those of the Lean- PBS groups at 12 h and 24 h (p < 0.05). Interestingly, the SC apoptosis rates in the DIO-E. coli groups were lower than those of the Lean-E. coli groups at 12 h (p < 0.05). In conclusion, our results suggested that the DIO mice presented stronger anti-apoptotic abilities than Lean mice in non-fatal acute pneumonia induced by E. coli infection, which is more conducive to protecting the spleen and improving the immune defense ability of the body.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>32198370</pmid><doi>10.1038/s41598-020-62044-5</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Intranasal Animals Apoptosis Apoptosis - immunology BAX protein Bcl-2 protein bcl-2-Associated X Protein - biosynthesis Caspase 3 - biosynthesis Caspase 9 - biosynthesis Caspase-3 Caspase-9 Diet E coli Escherichia coli Escherichia coli - immunology Escherichia coli Infections - immunology Escherichia coli Infections - microbiology Escherichia coli Infections - mortality Histology Immune response Immune system Macrophages - immunology Male Megakaryocytes - immunology Mice Mice, Obese Neutrophils - immunology Obesity - immunology Pneumonia - immunology Pneumonia - microbiology Pneumonia - mortality Proto-Oncogene Proteins c-bcl-2 - biosynthesis Spleen Spleen - cytology Spleen - immunology |
| title | Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice |
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