Regulation of stomatal development by stomatal lineage miRNAs

Stomata in the plant epidermis play a critical role in growth and survival by controlling gas exchange, transpiration, and immunity to pathogens. Plants modulate stomatal cell fate and patterning through key transcriptional factors and signaling pathways.MicroRNAs (miRNAs) are known to contribute to...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2020-03, Vol.117 (11), p.6237-6245
Main Authors: Zhu, Jiali, Park, Ji-Hwan, Lee, Seulbee, Lee, Jae Ho, Hwang, Daehee, Kwak, June M., Kim, Yun Ju
Format: Article
Language:English
Subjects:
Biological Sciences
Cell fate
Critical components
Developmental plasticity
Epidermis
Gas exchange
Homeostasis
MicroRNAs
miRNA
Pattern formation
Regulators
Regulatory mechanisms (biology)
Stomata
Transcription factors
Transpiration
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Summary:Stomata in the plant epidermis play a critical role in growth and survival by controlling gas exchange, transpiration, and immunity to pathogens. Plants modulate stomatal cell fate and patterning through key transcriptional factors and signaling pathways.MicroRNAs (miRNAs) are known to contribute to developmental plasticity in multicellular organisms; however, no miRNAs appear to target the known regulators of stomatal development. It remains unclear as to whether miRNAs are involved in stomatal development. Here, we report highly dynamic, developmentally stage-specific miRNA expression profiles from stomatal lineage cells. We demonstrate that stomatal lineage miRNAs positively and negatively regulate stomatal formation and patterning to avoid clustered stomata. Target prediction of stomatal lineage miRNAs implicates potential cellular processes in stomatal development. We show that miR399- mediated PHO2 regulation, involved in phosphate homeostasis, contributes to the control of stomatal development. Our study demonstrates that miRNAs constitute a critical component in the regulatory mechanisms controlling stomatal development.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1919722117