Neuroprotection in glaucoma-electrophysiology

Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path,...

Full description

Saved in:
Bibliographic Details
Published in:Experimental and therapeutic medicine 2020-04, Vol.19 (4), p.2401-2405
Main Authors: Lestak, Jan, Fus, Ma
Format: Article
Language:English
Subjects:
Amino acids
Diagnostic imaging
Diseases
Glaucoma
Glutamate
Hypertension
Neurons
Photoreceptors
Physiological aspects
Positron emission tomography
Retina
Review
Signal transduction
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path, with the focus on glaucoma. The results of positron emission tomography, functional magnetic resonance imaging and mainly electrophysiological methods demonstrated pathogenesis of nerve cell damage in the visual pathway. Based on these conclusions, neuroprotection in glaucoma was proposed. This consists mainly of the reduction of the intraocular pressure. It is followed by a decrease of glutamate in the synaptic cleft and blockade of its binding to the NMDA receptors. The supply of energy substrates to altered nerve cells is also indispensable. Therapy should be systemic due to impairment of the complete visual path.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2020.8509