Corticosteroid-induced Kaposi's Sarcoma Revealed by Severe Anemia: A Case Report and Literature Review

We herein report a case of gastrointestinal (GI) Kaposi's sarcoma (KS) without cutaneous involvement in a 73-year-old man who had received immunosuppressive drugs for granulomatosis with polyangiitis. After one year of prednisolone use, he presented with tarry stool and severe anemia. Endoscopi...

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Bibliographic Details
Published in:Internal Medicine 2020/03/01, Vol.59(5), pp.625-631
Main Authors: Endo, Go, Nagata, Naoyoshi
Format: Article
Language:English
Subjects:
Anemia
Case Report
Case reports
CD34 antigen
Corticosteroids
Granulomatosis
granulomatosis with polyangiitis
HIV
Human immunodeficiency virus
immunosuppression
Immunosuppressive agents
Internal medicine
Kaposi's sarcoma
Kaposis sarcoma
Literature reviews
Prednisolone
steroid
Transplantation
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Summary:We herein report a case of gastrointestinal (GI) Kaposi's sarcoma (KS) without cutaneous involvement in a 73-year-old man who had received immunosuppressive drugs for granulomatosis with polyangiitis. After one year of prednisolone use, he presented with tarry stool and severe anemia. Endoscopic and pathological examinations revealed bright-reddish protruding lesions with proliferating spindle cells positive for D2-40, CD34, and HHV-8, which are definitively diagnostic of GI-KS. Drug-induced KS without HIV infection or transplantation is extremely rare, and its clinical features remain unknown. Therefore, we conducted a literature review of steroid-induced KS.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3394-19