Markedly Effective Steroid Treatment of Three Patients with Allergy-related Jackhammer Esophagus

We experienced marked efficacy with steroid treatment of three patients with jackhammer esophagus (JHE). An esophageal biopsy revealed eosinophilic esophagitis (EoE) in two patients. One of the patients without EoE had eosinophilia and an increased serum immunoglobulin E level, and endoscopic ultras...

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Bibliographic Details
Published in:Internal Medicine 2020/03/01, Vol.59(5), pp.633-639
Main Authors: Funaki, Yasushi, Ogasawara, Naotaka, Kawamura, Yurika, Yoshimine, Takashi, Tamura, Yasuhiro, Izawa, Shinya, Tsuyuki, Takuji, Ebi, Masahide, Sasaki, Makoto, Kasugai, Kunio
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
Allergies
Biopsy
Case Report
Endosonography
Eosinophilia
eosinophilic esophagitis
Eosinophilic Esophagitis - complications
Esophageal Motility Disorders - complications
Esophageal Motility Disorders - drug therapy
Esophagitis
Esophagus
Female
gastroesophageal reflux disease
high-resolution manometry
Humans
Immunoglobulin E
Immunoglobulin E - blood
Internal medicine
Jackhammer esophagus
Leukocytes (eosinophilic)
Male
Manometry
Middle Aged
prednisolone
Treatment Outcome
Ultrasound
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Summary:We experienced marked efficacy with steroid treatment of three patients with jackhammer esophagus (JHE). An esophageal biopsy revealed eosinophilic esophagitis (EoE) in two patients. One of the patients without EoE had eosinophilia and an increased serum immunoglobulin E level, and endoscopic ultrasonography revealed thickening of the esophageal muscularis propria. Esophageal manometry was used to diagnose all cases of JHE. Treatment consisted of steroid administration, which improved the symptoms and resolved the esophageal muscularis propria thickening in all patients. The esophageal manometry findings also normalized following treatment. Allergic diseases, including EoE, were assumed to have caused JHE.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3865-19