Antigenic and biological diversity of feline coronaviruses: feline infectious peritonitis and feline enteritis virus

Antigenically related feline coronaviruses cause two distinct disease manifestations in infected cats. The diseases are feline infectious peritonitis (FIP), in which the virus is widely disseminated, and feline enteric coronavirus (FECV), a mild disease in which the virus is usually limited to the v...

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Bibliographic Details
Published in:Archives of virology 1987-01, Vol.96 (1/2), p.29-38
Main Authors: Tupper, G.T, Evermann, J.F, Russell, R.G, Thouless, M.E
Format: Article
Language:English
Subjects:
Animals
antigens
Antigens, Viral - analysis
Antigens, Viral - immunology
Biological and medical sciences
Cats
Cell Line
Coronaviridae
Coronaviridae - growth & development
Coronaviridae - immunology
Coronaviridae - physiology
Cytopathogenic Effect, Viral
Electrophoresis, Polyacrylamide Gel
enteritis
feline peritonitis virus
Fundamental and applied biological sciences. Psychology
Microbiology
Neutralization Tests
Nucleoproteins - analysis
Original Papers
Protein Biosynthesis
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Viral Plaque Assay
Viral Proteins - analysis
Viral Proteins - biosynthesis
Virology
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Summary:Antigenically related feline coronaviruses cause two distinct disease manifestations in infected cats. The diseases are feline infectious peritonitis (FIP), in which the virus is widely disseminated, and feline enteric coronavirus (FECV), a mild disease in which the virus is usually limited to the villi. These two viruses were found to differ in their growth in cell culture. FIPV grows to higher titer, forms larger plaques and switches off host cell protein synthesis more effectively than FECV. Cross neutralization studies showed antigenic differences between the strains. There also appeared to be a difference in the nucleoprotein molecular weight of the viruses causing these two different disease syndromes.
ISSN:0304-8608
1432-8798
DOI:10.1007/bf01310988