Molecular characteristics of a novel strain of canine minute virus associated with hepatitis in a dog

A 5-year-old female Yorkshire terrier dog died a few days following hernia and ovariohysterectomy surgeries. Necropsy performed on the dog revealed that the surgeries were not the cause of death; however, degenerative viral hepatitis, showing intranuclear inclusion bodies in hepatic cells, was obser...

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Bibliographic Details
Published in:Archives of virology 2016-08, Vol.161 (8), p.2299-2304
Main Authors: Choi, Jeong-Won, Jung, Ji-Youl, Lee, Jae-Il, Lee, Kyoung-Ki, Oem, Jae-Ku
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bocavirus - classification
Bocavirus - genetics
Bocavirus - isolation & purification
Brief Report
Canine minute virus
Dog Diseases - pathology
Dog Diseases - virology
Dogs
Environmental research
Female
Gastroenteritis
Genomes
Hepatitis
Hepatitis - pathology
Hepatitis - virology
Hernias
Hybridization
Infectious Diseases
Liver - pathology
Liver - virology
Medical Microbiology
Parvoviridae Infections - pathology
Parvoviridae Infections - veterinary
Parvoviridae Infections - virology
Phylogenetics
Phylogeny
Viral Proteins - genetics
Virology
Viruses
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Summary:A 5-year-old female Yorkshire terrier dog died a few days following hernia and ovariohysterectomy surgeries. Necropsy performed on the dog revealed that the surgeries were not the cause of death; however, degenerative viral hepatitis, showing intranuclear inclusion bodies in hepatic cells, was observed in histopathologic examination. Several diagnostic methods were used to screen for the cause of disease, and minute virus of canines (MVC) was detected in all parenchymal organs, including the liver. Other pathogens that may cause degenerative viral hepatitis were not found. Infection with MVC was confirmed by in situ hybridization, which revealed the presence of MVC nucleic acid in the liver tissue of the dog. Through sequencing and phylogenetic analysis of the nearly complete genome sequence, the strain was found to be distinct from other previously reported MVC strains. These results indicate that this novel MVC strain might be related to degenerative viral hepatitis in dogs.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-016-2895-7