Molecular Analysis of an Outbreak of Influenza in the United Kingdom

The first outbreak of influenza virus in Europe in 1995/1996 occurred in a school in the south of England. RT-PCR-restriction analysis was performed on the HA1 portion of influenza haemagglutinin gene amplified directly from clinical samples. These were taken at the onset of the outbreak and indicat...

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Bibliographic Details
Published in:European journal of epidemiology 1997-06, Vol.13 (4), p.369-372
Main Authors: Ellis, J. S., Zambon, M. C.
Format: Article
Language:English
Subjects:
Adolescent
Amino Acid Sequence
Antigens
Biological and medical sciences
Boarding schools
Boys
Disease Outbreaks
Diseases
England - epidemiology
Genetic diversity
Genetic variance
Genetic Variation
H3N2 subtype influenza A virus
Human viral diseases
Humans
Infections
Infectious diseases
Influenza
Influenza A virus
Influenza A virus - classification
Influenza A virus - genetics
Influenza, Human - epidemiology
Influenza, Human - virology
Male
Medical genetics
Medical sciences
Molecular Epidemiology - methods
Molecular Sequence Data
Mutation
Orthomyxoviridae
Outbreaks
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Population Surveillance
Public health
Respiratory diseases
Reverse transcriptase polymerase chain reaction
Schools
Serotyping
Surveillance
Vaccines
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
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Description
Summary:The first outbreak of influenza virus in Europe in 1995/1996 occurred in a school in the south of England. RT-PCR-restriction analysis was performed on the HA1 portion of influenza haemagglutinin gene amplified directly from clinical samples. These were taken at the onset of the outbreak and indicated co-circulation of two distinct genetic variants of influenza virus which were antigenically identical. Investigations of this nature demonstrate the genetic diversity of circulating variants of influenza and have the potential to provide information on molecular evolution of strains within closed populations.
ISSN:0393-2990
1573-7284
DOI:10.1023/A:1007391222905