Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters

Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N -hydroxybenzotriazole or N -hydroxysuccinimide with N , N ′-dicyclohexylcarbodiimide. GA conjugate with D-Trp e...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2017, Vol.43 (4), p.456-462
Main Authors: Fayrushina, A. I., Baltina, L. A., Konovalova, N. I., Petrova, P. A., Eropkin, M. Yu
Format: Article
Language:English
Subjects:
Amino acids
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Conjugates
Esters
Ethyl esters
Influenza
Life Sciences
Organic Chemistry
Viruses
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Summary:Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N -hydroxybenzotriazole or N -hydroxysuccinimide with N , N ′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162017040045