Carbohydrate biomarkers for future disease detection and treatment

Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate “binders” that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific deliver...

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Bibliographic Details
Published in:Science China Chemistry 2010, Vol.53 (1), p.3-20
Main Authors: Cheng, YunFeng, Li, MinYong, Wang, ShaoRu, Peng, HanJing, Reid, Suazette, Ni, NanTing, Fang, Hao, Xu, WenFang, Wang, BingHe
Format: Article
Language:English
Subjects:
Biomarkers
Carbohydrates
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Infectious diseases
Pharmacology
Reviews
Stem cells
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Summary:Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate “binders” that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and (7) cardiovascular diseases, though some issues cross therapeutic boundaries.
ISSN:1674-7291
1862-2771
1869-1870
DOI:10.1007/s11426-010-0021-3