A novel human coronavirus： Middle East respiratory syndrome human coronavirus

In 2012, a novel coronavirus, initially named as human coronavirus EMC （HCoV-EMC） but recently renamed as Middle East respiratory syndrome human coronavirus （MERS-CoV）, was identified in patients who suffered severe acute respiratory infec- tion and subsequent renal failure that resulted in death. O...

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Bibliographic Details
Published in:Science China. Life sciences 2013-08, Vol.56 (8), p.683-687
Main Authors: Geng, HeYuan, Tan, WenJie
Format: Article
Language:English
Subjects:
Adult
Aged
Base Sequence
Biomedical and Life Sciences
Coronavirus
Coronavirus - genetics
Coronavirus - isolation & purification
Coronavirus - pathogenicity
Coronavirus Infections - virology
Coronaviruses
DNA, Viral - genetics
Genome, Viral
Humans
Life Sciences
Male
Middle Aged
Middle East
Phylogeny
Respiratory Tract Infections - virology
Review
Syndrome
中东
人类
冠状病毒
呼吸综合征
基因组序列
急性呼吸道感染
流行病学调查
间接免疫荧光法
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Summary:In 2012, a novel coronavirus, initially named as human coronavirus EMC （HCoV-EMC） but recently renamed as Middle East respiratory syndrome human coronavirus （MERS-CoV）, was identified in patients who suffered severe acute respiratory infec- tion and subsequent renal failure that resulted in death. Ongoing epidemiological investigations together with retrospective studies have found 61 laboratory-confirmed cases of infection with this novel coronavirus, including 34 deaths to date. This novel coronavirus is culturable and two complete genome sequences are now available. Furthermore, molecular detection and indirect immunofluorescence assay have been developed. The present paper summarises the limited recent advances of this novel human coronavirus, including its discovery, genomic characterisation and detection.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-013-4519-8