Liver function after transplantation in the assessment of the coagulation system and the concept of antithrombotic therapy

• Published in: Przegląd gastroenterologiczny 2020, Vol.15 (1), p.48-54
• Main Authors: Lukaszewski, Marceli, Jakubaszko, Jacek, Bielicki, Grzegorz, Koscielska-Kasprzak, Katarzyna, Kosiorowska, Kinga
• Format: Article
• Language: English
• Subjects: Anesthesiology; Anticoagulants; Enzymes; Gastroenterology; Intensive care; Laboratories; Liver diseases; Liver transplants; Metabolism; Original Paper; Physiology; Surgery; Thrombosis
• ISSN: 1895-5770; 1897-4317
• DOI: 10.5114/pg.2020.93631

Thrombotic complications after liver transplantation limit the long-term success of the procedure. Therefore, an early and accurate diagnosis with the appropriate treatment is crucial to sustain the proper functioning of the graft. To evaluate the return of newly transplanted liver function within the first days of ICU stay after liver transplantation surgery (Ltx) observed in laboratory examination. It is important to understand the physiology of the newly transplanted liver, particularly in terms of its metabolic function and the assessment of easy-to-monitor coagulation parameters and enzyme markers. We present our observations carried out in 27 patients, transplanted in the period 2015-2017, during their stay in the Department of Anaesthesiology and Intensive Therapy of the University Hospital in Wroclaw. We demonstrated changes in laboratory parameters within 72 h after liver transplantation and the concept of anticoagulant therapy at our institution. The presented results show the characteristics of aspartate transaminase, alanine transaminase, bilirubin, and standard tests evaluating the coagulation system within the first 4 days after surgery. The concept of anticoagulant therapy used in our intensive care unit is also presented. The aim of the work is an observation of physiology of the graft function in the aspect of coagulation disorders. The early postoperative period is considered prognostic. The characteristics of basic biochemical tests are determined by the function of the transplanted organ. Implementation of anticoagulant therapy in this period is a therapeutic challenge that requires experience.