Non-targeted urinary metabolomics in pregnancy and associations with fetal growth restriction

Our objective was to identify metabolites associated with fetal growth restriction (FGR) by examining early and late pregnancy differences in non-targeted urinary metabolites among FGR cases and non-FGR controls. An exploratory case-control study within LIFECODES birth cohort was performed. FGR case...

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Bibliographic Details
Published in:Scientific reports 2020-03, Vol.10 (1), p.5307, Article 5307
Main Authors: Clinton, Chelsea M., Bain, James R., Muehlbauer, Michael J., Li, YuanYuan, Li, Leping, O’Neal, Sara K., Hughes, Brenna L., Cantonwine, David E., Mcelrath, Thomas F., Ferguson, Kelly K.
Format: Article
Language:English
Subjects:
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Adult
Benzoic acid
Biomarkers - urine
Birth Weight
Body mass index
Case-Control Studies
Female
Fetal Growth Retardation - diagnosis
Fetal Growth Retardation - urine
Fetuses
Gas chromatography
Gestational Age
Health risk assessment
Humanities and Social Sciences
Humans
Infant, Newborn
Infant, Small for Gestational Age - metabolism
Ionization
Mass spectrometry
Mass spectroscopy
Maternal Age
Metabolites
Metabolome
Metabolomics
multidisciplinary
Organic acids
Pregnancy
Prenatal development
Science
Science (multidisciplinary)
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Summary:Our objective was to identify metabolites associated with fetal growth restriction (FGR) by examining early and late pregnancy differences in non-targeted urinary metabolites among FGR cases and non-FGR controls. An exploratory case-control study within LIFECODES birth cohort was performed. FGR cases (N = 30), defined as birthweight below the 10 th percentile, were matched with controls (N = 30) based on maternal age, race, pre-pregnancy body mass index, and gestational age at delivery. Gas chromatography/electron-ionization mass spectrometry was performed on urine samples collected at 10 and 26 weeks of gestation. Differences in urinary metabolite levels in cases and controls at each time point and between the two time points were calculated and then changes compared across pregnancy. 137 unique urinary metabolites were annotated, and several identified that were higher in cases compared to controls. For example, urinary concentrations of benzoic acid were higher in cases compared to controls at both study visits (3.01-fold higher in cases at visit 1, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-62131-7