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High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis
The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 cl...
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Published in: | Indian journal of clinical biochemistry 2020-04, Vol.35 (2), p.211-217 |
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description | The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years. hs CRP levels were estimated in the cases and healthy controls using ELISA. Median levels of serum hs CRP were significantly higher in pediatric tuberculosis cases (25 mg/l) as compared to controls (0.530 mg/l). No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. Further studies could help in determining the prognostic and therapeutic response of hs CRP among children leading to better management. |
doi_str_mv | 10.1007/s12291-018-0806-2 |
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No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. Further studies could help in determining the prognostic and therapeutic response of hs CRP among children leading to better management.</description><identifier>ISSN: 0970-1915</identifier><identifier>EISSN: 0974-0422</identifier><identifier>DOI: 10.1007/s12291-018-0806-2</identifier><identifier>PMID: 32226253</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; C-reactive protein ; Chemistry/Food Science ; Children ; Diagnosis ; Enzyme-linked immunosorbent assay ; Life Sciences ; Lymphadenopathy ; Mantoux test ; Medical research ; Medicine, Experimental ; Microbiology ; Nucleic acids ; Original ; Original Research Article ; Pathology ; Pediatrics ; Prognosis ; Radiography ; Tuberculosis</subject><ispartof>Indian journal of clinical biochemistry, 2020-04, Vol.35 (2), p.211-217</ispartof><rights>Association of Clinical Biochemists of India 2019</rights><rights>Association of Clinical Biochemists of India 2019.</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Indian Journal of Clinical Biochemistry is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>2019© Association of Clinical Biochemists of India 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-5d8c6f27c9e8cb6bfcdb957eecb4864e4a7513f29d36fdb22d2f8f9e57501dc93</citedby><cites>FETCH-LOGICAL-c599t-5d8c6f27c9e8cb6bfcdb957eecb4864e4a7513f29d36fdb22d2f8f9e57501dc93</cites><orcidid>0000-0003-2471-4078</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093649/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093649/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32226253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashyap, Bineeta</creatorcontrib><creatorcontrib>Gupta, Neha</creatorcontrib><creatorcontrib>Dewan, Pooja</creatorcontrib><creatorcontrib>Hyanki, Puneeta</creatorcontrib><creatorcontrib>Singh, N. P.</creatorcontrib><title>High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis</title><title>Indian journal of clinical biochemistry</title><addtitle>Ind J Clin Biochem</addtitle><addtitle>Indian J Clin Biochem</addtitle><description>The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years. hs CRP levels were estimated in the cases and healthy controls using ELISA. Median levels of serum hs CRP were significantly higher in pediatric tuberculosis cases (25 mg/l) as compared to controls (0.530 mg/l). No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. Further studies could help in determining the prognostic and therapeutic response of hs CRP among children leading to better management.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>C-reactive protein</subject><subject>Chemistry/Food Science</subject><subject>Children</subject><subject>Diagnosis</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Life Sciences</subject><subject>Lymphadenopathy</subject><subject>Mantoux test</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Microbiology</subject><subject>Nucleic acids</subject><subject>Original</subject><subject>Original Research Article</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Radiography</subject><subject>Tuberculosis</subject><issn>0970-1915</issn><issn>0974-0422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kstu1DAUhiMEoqXwAGyQJTawSLEdJ7FZII2GSytVajUtWyzHOUk9ytitLxV9exymtAwC5IUv5zu_fY7_onhJ8CHBuH0XCKWClJjwEnPclPRRsY9Fy0rMKH38c41LIki9VzwLYY1xxTAjT4u9ilLa0LraL74dmfESnYMNJpobE2_REq1A6bwBdOZdBGPfo4VFi36drI7oo1GjdcEEZCxapcnYEZ2miM6gNyp6o9FF6sDrNM3Q8-LJoKYAL-7mg-Lr508Xy6Py5PTL8XJxUupaiFjWPdfNQFstgOuu6Qbdd6JuAXTHeMOAqbYm1UBFXzVD31Ha04EPAuq2xqTXojooPmx1r1K3gV6DjV5N8sqbjfK30ikjdyPWXMrR3cgWi6phs8CbOwHvrhOEKDcmaJgmZcGlIGnFGWe5aTSjr_9A1y55m8ubKdpSyqvqvxTJMg3jhDxQo5pAGju4_Do9Xy0XLWEsfytvMnX4FyqPHjZGOwuDyec7CW93EjIT4XscVQpBHp-vdlmyZbV3IXgY7rtGsJxtJrc2k9lmcraZnFvw6vd232f88lUG6BYIOWRH8A_V_1v1B88h2vk</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Kashyap, Bineeta</creator><creator>Gupta, Neha</creator><creator>Dewan, Pooja</creator><creator>Hyanki, Puneeta</creator><creator>Singh, N. 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P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-5d8c6f27c9e8cb6bfcdb957eecb4864e4a7513f29d36fdb22d2f8f9e57501dc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>C-reactive protein</topic><topic>Chemistry/Food Science</topic><topic>Children</topic><topic>Diagnosis</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Life Sciences</topic><topic>Lymphadenopathy</topic><topic>Mantoux test</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Microbiology</topic><topic>Nucleic acids</topic><topic>Original</topic><topic>Original Research Article</topic><topic>Pathology</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Radiography</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashyap, Bineeta</creatorcontrib><creatorcontrib>Gupta, Neha</creatorcontrib><creatorcontrib>Dewan, Pooja</creatorcontrib><creatorcontrib>Hyanki, Puneeta</creatorcontrib><creatorcontrib>Singh, N. 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P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><stitle>Ind J Clin Biochem</stitle><addtitle>Indian J Clin Biochem</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>35</volume><issue>2</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>0970-1915</issn><eissn>0974-0422</eissn><abstract>The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years. hs CRP levels were estimated in the cases and healthy controls using ELISA. Median levels of serum hs CRP were significantly higher in pediatric tuberculosis cases (25 mg/l) as compared to controls (0.530 mg/l). No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. 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subjects | Biochemistry Biomedical and Life Sciences C-reactive protein Chemistry/Food Science Children Diagnosis Enzyme-linked immunosorbent assay Life Sciences Lymphadenopathy Mantoux test Medical research Medicine, Experimental Microbiology Nucleic acids Original Original Research Article Pathology Pediatrics Prognosis Radiography Tuberculosis |
title | High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis |
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