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High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis

The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 cl...

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Published in:Indian journal of clinical biochemistry 2020-04, Vol.35 (2), p.211-217
Main Authors: Kashyap, Bineeta, Gupta, Neha, Dewan, Pooja, Hyanki, Puneeta, Singh, N. P.
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description The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years. hs CRP levels were estimated in the cases and healthy controls using ELISA. Median levels of serum hs CRP were significantly higher in pediatric tuberculosis cases (25 mg/l) as compared to controls (0.530 mg/l). No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. Further studies could help in determining the prognostic and therapeutic response of hs CRP among children leading to better management.
doi_str_mv 10.1007/s12291-018-0806-2
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source PubMed (Medline); Springer Link
subjects Biochemistry
Biomedical and Life Sciences
C-reactive protein
Chemistry/Food Science
Children
Diagnosis
Enzyme-linked immunosorbent assay
Life Sciences
Lymphadenopathy
Mantoux test
Medical research
Medicine, Experimental
Microbiology
Nucleic acids
Original
Original Research Article
Pathology
Pediatrics
Prognosis
Radiography
Tuberculosis
title High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis
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