Urocystitis and Ureteritis in Holstein Calves with Septicaemia Caused by Salmonella enterica Serotype Dublin

Salmonellosis is an enteric or multisystemic disease of global distribution that affects numerous animal species. Although Salmonella enterica has been associated with urinary tract lesions in man, information on urocystitis/ureteritis in cattle caused by salmonellae is lacking. This communication d...

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Bibliographic Details
Published in:Journal of comparative pathology 2018-10, Vol.164, p.32-36
Main Authors: Costa, R.A., Casaux, M.L., Caffarena, R.D., Macías-Rioseco, M., Schild, C.O., Fraga, M., Riet-Correa, F., Giannitti, F.
Format: Article
Language:English
Subjects:
Animals
Cattle
Cattle Diseases - microbiology
Cattle Diseases - pathology
pathology
Salmonella enterica
Salmonella Infections, Animal - pathology
salmonellosis
Sepsis - veterinary
urinary tract infection
Urinary Tract Infections - veterinary
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Summary:Salmonellosis is an enteric or multisystemic disease of global distribution that affects numerous animal species. Although Salmonella enterica has been associated with urinary tract lesions in man, information on urocystitis/ureteritis in cattle caused by salmonellae is lacking. This communication describes lesions of the inferior urinary tract in four Holstein calves with septicaemia caused by S. enterica subsp. enterica serotype Dublin. Examination of the urinary bladder revealed either diffuse irregular thickening (three cases) or petechiation (one case) of the mucosa. On histopathological examination, urocystitis with submucosal histiocytic, lymphocytic and plasmacytic infiltration and neutrophil transmigration through the urothelium was noted in all cases. In one case, a fibrinosuppurative ureteritis was detected. Salmonella Dublin was identified by culture, 16S rDNA sequencing and serotyping and Salmonella antigen was detected intralesionally by immunohistochemistry. Other lesions, indicative of septicaemia included hepatitis, enteritis, pericarditis, splenitis, lymphadenitis and pneumonia. We conclude that S. Dublin can be uropathogenic in cattle with septicaemia.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2018.08.005