Searching for the cause of Kawasaki disease - cytoplasmic inclusion bodies provide new insight

Although Kawasaki disease (KD) is the most common cause of acquired heart disease in children in the developed world, its aetiology remains unknown. In this Opinion, Anne Rowley and colleagues discuss evidence, including recently identified cytoplasmic inclusion bodies, which suggests that KD is cau...

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Bibliographic Details
Published in:Nature reviews. Microbiology 2008-05, Vol.6 (5), p.394-401
Main Authors: Rowley, Anne H, Baker, Susan C, Orenstein, Jan M, Shulman, Stanford T
Format: Article
Language:English
Subjects:
Adult
Antigens
Antigens - analysis
Antigens - immunology
Biomedical and Life Sciences
Cardiovascular diseases
Care and treatment
Child
Coronary Aneurysm - immunology
Coronary Aneurysm - pathology
Cytoplasm - immunology
Diagnosis
Diseases
Epidemiology
Evolution
Genes
Genomes
Genomics
Heart diseases
Humans
Immunoglobulin A
Immunoglobulin A - analysis
Immunoglobulin A - immunology
Inclusion Bodies - immunology
Infectious Diseases
Kawasaki disease
Kawasaki syndrome
Laboratories
Life Sciences
Medical Microbiology
Medical schools
Microbiology
Mucocutaneous Lymph Node Syndrome - complications
Mucocutaneous Lymph Node Syndrome - immunology
Mucocutaneous Lymph Node Syndrome - pathology
opinion-2
Parasitology
Pathogens
Pediatric cardiology
Pediatric diseases
Phylogenetics
Plasma Cells - immunology
Polymorphism
Prevention
Proteins
Risk factors
Tuberculosis
Vaccines
Virology
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Description
Summary:Although Kawasaki disease (KD) is the most common cause of acquired heart disease in children in the developed world, its aetiology remains unknown. In this Opinion, Anne Rowley and colleagues discuss evidence, including recently identified cytoplasmic inclusion bodies, which suggests that KD is caused by an infectious agent. Kawasaki disease (KD) has emerged as the most common cause of acquired heart disease in children in the developed world. The cause of KD remains unknown, although an as-yet unidentified infectious agent might be responsible. By determining the causative agent, we can improve diagnosis, therapy and prevention of KD. Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the mysteries of KD.
ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro1853