Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

IMPORTANCE: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. OBJECTIVE: To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with sever...

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Bibliographic Details
Published in:JAMA 2020-04, Vol.323 (16), p.1582-1589
Main Authors: Shen, Chenguang, Wang, Zhaoqin, Zhao, Fang, Yang, Yang, Li, Jinxiu, Yuan, Jing, Wang, Fuxiang, Li, Delin, Yang, Minghui, Xing, Li, Wei, Jinli, Xiao, Haixia, Yang, Yan, Qu, Jiuxin, Qing, Ling, Chen, Li, Xu, Zhixiang, Peng, Ling, Li, Yanjie, Zheng, Haixia, Chen, Feng, Huang, Kun, Jiang, Yujing, Liu, Dongjing, Zhang, Zheng, Liu, Yingxia, Liu, Lei
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies
Antibodies, Neutralizing - therapeutic use
Antibodies, Viral - blood
Antibodies, Viral - therapeutic use
Antiviral agents
Antiviral Agents - therapeutic use
Betacoronavirus - immunology
Blood Donors
Body temperature
Chemical compounds
Clinical trials
Coronavirus Infections - drug therapy
Coronavirus Infections - physiopathology
Coronavirus Infections - therapy
Coronaviruses
COVID-19
Critical Illness
Dilution
Enzyme-linked immunosorbent assay
Female
Glucocorticoids - therapeutic use
Health services
Humans
Immunization, Passive
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin M - blood
Infectious diseases
Male
Mechanical ventilation
Methylprednisolone
Methylprednisolone - therapeutic use
Middle Aged
Neutralization
Neutralizing
Online First
Organ Dysfunction Scores
Oxygenation
Pandemics
Patients
Pharmacology
Plasma
Pneumonia, Viral - drug therapy
Pneumonia, Viral - physiopathology
Pneumonia, Viral - therapy
Preliminary Communication
Respiratory diseases
Respiratory distress syndrome
Respiratory Distress Syndrome - therapy
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Transfusion
Ventilation
Ventilators
Viral diseases
Citations: Items that this one cites
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Summary:IMPORTANCE: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. OBJECTIVE: To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DESIGN, SETTING, AND PARTICIPANTS: Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao2/Fio2
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2020.4783