Protein oxidation at the air-lung interface

Whilst performing its normal functions the lung is required to deal with a range of toxic insults. Whether these are infectious agents, allergens or air pollutants they subject the lung to a range of direct and indirect oxidative stresses. In many instances these challenges lead to oxidative alterat...

Full description

Saved in:
Bibliographic Details
Published in:Amino acids 2003-12, Vol.25 (3-4), p.375-396
Main Authors: Kelly, F. J, Mudway, I. S
Format: Article
Language:English
Subjects:
air
air pollution
allergens
Animals
antioxidants
Antioxidants - metabolism
Cysteine - metabolism
Humans
Lung - chemistry
Lung - metabolism
lung function
Methionine - metabolism
Nitrogen Dioxide - toxicity
Nitrosation
Oxidation
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Ozone - toxicity
pathogens
peptides
pollutants
Proteins
Proteins - drug effects
Proteins - metabolism
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - metabolism
Review
Sulfhydryl Compounds - metabolism
toxicity
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whilst performing its normal functions the lung is required to deal with a range of toxic insults. Whether these are infectious agents, allergens or air pollutants they subject the lung to a range of direct and indirect oxidative stresses. In many instances these challenges lead to oxidative alterations of peptides and proteins within the lung. Measurement of protein oxidation products permits the degree of oxidative stress to be assessed and indicates that endogenous antioxidant defences are overwhelmed. The range of protein oxidation products observed is diverse and the nature and extent of specific oxidation products may inform us about the nature of the damaging ROS and NOS. Recently, there has been a significant shift away from the measurement of these oxidation products simply to establish the presence of oxidative stress, to a focus on identifying specific proteins sensitive to oxidation and establishing the functional consequences of these modifications. In addition the identification of specific enzyme systems to repair these oxidative modifications has lead to the belief that protein function may be regulated through these oxidation reactions. In this review we focus primarily on the soluble protein components of within the surface liquid layer in the lung and the consequence of their undue oxidation.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-003-0024-x