Severe adenovirus pneumonia in immunocompetent adults: a case report and review of the literature

Adenovirus is a frequent cause of mild self-limiting upper respiratory tract infection, gastroenteritis, and conjunctivitis in infants and young children. Fatal infections (severe pneumonia progressing to respiratory failure, septic shock and/or encephalitis) are rare among immunocompetent adults. W...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2008-02, Vol.27 (2), p.153-158
Main Authors: Hakim, F. A., Tleyjeh, I. M.
Format: Article
Language:English
Subjects:
Adenoviridae - isolation & purification
Adenoviridae Infections - complications
Adenoviridae Infections - therapy
Adenoviridae Infections - virology
Adenovirus
Adolescent
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Case Report
Case reports
Children
Conjunctivitis
Encephalitis
Epidemics
Female
Gastroenteritis
Human viral diseases
Humans
Infants
Infection
Infectious diseases
Internal Medicine
Literature reviews
Male
Medical Microbiology
Medical sciences
Middle Aged
Pneumonia
Pneumonia, Viral - complications
Pneumonia, Viral - therapy
Pneumonia, Viral - virology
Respiration, Artificial
Respiratory Insufficiency
Respiratory tract
Respiratory tract diseases
Septic shock
Ventilators, Mechanical
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
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Summary:Adenovirus is a frequent cause of mild self-limiting upper respiratory tract infection, gastroenteritis, and conjunctivitis in infants and young children. Fatal infections (severe pneumonia progressing to respiratory failure, septic shock and/or encephalitis) are rare among immunocompetent adults. We report a case of severe adenovirus pneumonia in a young immunocompetent male who presented with sudden onset respiratory distress that progressed rapidly to respiratory failure and made a successful recovery on supportive measures. Systematic review of the literature identified 14 cases of severe adenovirus pneumonia (defined as respiratory failure requiring ventilatory support at any point during the course of illness) in otherwise healthy immunocompetent adults both in epidemic and community settings. We describe the clinical characteristics, radiological features, and outcome of identified cases.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-007-0416-z