SARS-CoV and IFN: Too Little, Too Late

Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopatholog...

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Bibliographic Details
Published in:Cell host & microbe 2016-02, Vol.19 (2), p.139-141
Main Authors: Kindler, Eveline, Thiel, Volker
Format: Article
Language:English
Subjects:
Animals
Interferon Type I
Lung - virology
SARS Virus
Virus Replication
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Summary:Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopathology, with fatal outcomes. Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopathology, with fatal outcomes.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2016.01.012