Life, death, and autophagy in cancer: NF-κB turns up everywhere

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating th...

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Bibliographic Details
Published in:Cell death & disease 2020-03, Vol.11 (3), p.210-210, Article 210
Main Authors: Verzella, Daniela, Pescatore, Alessandra, Capece, Daria, Vecchiotti, Davide, Ursini, Matilde Valeria, Franzoso, Guido, Alesse, Edoardo, Zazzeroni, Francesca
Format: Article
Language:English
Subjects:
631/67
631/80/82
Antibodies
Apoptosis
Autophagy
Biochemistry
Biomedical and Life Sciences
Cancer
Cell Biology
Cell Culture
Cell death
Cell survival
Humans
Immunology
Life Sciences
Necroptosis
Neoplasms - genetics
NF-kappa B - metabolism
NF-κB protein
Phagocytosis
Review
Review Article
Signal Transduction
Transcription factors
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Summary:Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.
ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-020-2399-y