Human pegivirus detected in a patient with severe encephalitis using a metagenomic pan-virus array

Highlights • Metagenomic microarray for unbiased detection of virus in patient samples. • Discovery of an occult viral infection, HPgV, in the spinal fluid of a patient with severe encephalitis. • HPgV can on rare occasions enter the CSF at high viral load, but uncertain if its presence in the CNS h...

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Bibliographic Details
Published in:Journal of clinical virology 2016-04, Vol.77, p.5-8
Main Authors: Fridholm, Helena, Østergaard Sørensen, Line, Rosenstierne, Maiken W, Nielsen, Henrik, Sellebjerg, Finn, Bengård Andersen, Åse, Fomsgaard, Anders
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Encephalitis
Encephalitis, Viral - diagnosis
Encephalitis, Viral - virology
Female
Flaviviridae - classification
Flaviviridae - genetics
HPgV
Humans
Infectious Disease
Metagenomics
Metagenomics - methods
Microarray
Real-Time Polymerase Chain Reaction
Serologic Tests
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Summary:Highlights • Metagenomic microarray for unbiased detection of virus in patient samples. • Discovery of an occult viral infection, HPgV, in the spinal fluid of a patient with severe encephalitis. • HPgV can on rare occasions enter the CSF at high viral load, but uncertain if its presence in the CNS has any clinical implications.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2016.01.013