Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients

Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 an...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 2014-01, Vol.209 (2), p.300-303
Main Authors: Lhomme, Sebastien, Garrouste, Cyril, Kamar, Nassim, Saune, Karine, Abravanel, Florence, Mansuy, Jean-Michel, Dubois, Martine, Rostaing, Lionel, Izopet, Jacques
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chronic Disease
Entropy
Female
Fundamental and applied biological sciences. Psychology
Genetic Heterogeneity
Genotypes
Hepatitis E
Hepatitis E - immunology
Hepatitis E - virology
Hepatitis E virus
Hepatitis E virus - genetics
Hepatitis E virus - immunology
Humans
Immune response
Immunocompromised Host
Infections
Infectious diseases
Major and Brief Reports
Male
Medical sciences
Microbiology
Middle Aged
Organ Transplantation - adverse effects
PARASITES
Peptides - genetics
Peptides - immunology
Polymerase chain reaction
RNA
Transplantation
Viral Proteins - genetics
Viral Proteins - immunology
Viruses
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Summary:Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solidorgan transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jit438