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Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients
Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 an...
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| Published in: | The Journal of Infectious Diseases 2014-01, Vol.209 (2), p.300-303 |
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| cites | cdi_FETCH-LOGICAL-c566t-2a285a5e2ba77896625822d95699ac182d17718577c4ffc49d35aa7183e4f3c53 |
| container_end_page | 303 |
| container_issue | 2 |
| container_start_page | 300 |
| container_title | The Journal of Infectious Diseases |
| container_volume | 209 |
| creator | Lhomme, Sebastien Garrouste, Cyril Kamar, Nassim Saune, Karine Abravanel, Florence Mansuy, Jean-Michel Dubois, Martine Rostaing, Lionel Izopet, Jacques |
| description | Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solidorgan transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence. |
| doi_str_mv | 10.1093/infdis/jit438 |
| format | article |
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The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solidorgan transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jit438</identifier><identifier>PMID: 23964111</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Biological and medical sciences ; Chronic Disease ; Entropy ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Heterogeneity ; Genotypes ; Hepatitis E ; Hepatitis E - immunology ; Hepatitis E - virology ; Hepatitis E virus ; Hepatitis E virus - genetics ; Hepatitis E virus - immunology ; Humans ; Immune response ; Immunocompromised Host ; Infections ; Infectious diseases ; Major and Brief Reports ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Organ Transplantation - adverse effects ; PARASITES ; Peptides - genetics ; Peptides - immunology ; Polymerase chain reaction ; RNA ; Transplantation ; Viral Proteins - genetics ; Viral Proteins - immunology ; Viruses</subject><ispartof>The Journal of Infectious Diseases, 2014-01, Vol.209 (2), p.300-303</ispartof><rights>Copyright © 2014 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>2015 INIST-CNRS</rights><rights>2013. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://academic.oup.com/journals/pages/coronavirus .</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: . 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-2a285a5e2ba77896625822d95699ac182d17718577c4ffc49d35aa7183e4f3c53</citedby><cites>FETCH-LOGICAL-c566t-2a285a5e2ba77896625822d95699ac182d17718577c4ffc49d35aa7183e4f3c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43707961$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2406231692?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,38516,43895,58238,58471</link.rule.ids><linktorsrc>$$Uhttps://www.proquest.com/docview/2406231692?pq-origsite=primo$$EView_record_in_ProQuest$$FView_record_in_$$GProQuest</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28319683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23964111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lhomme, Sebastien</creatorcontrib><creatorcontrib>Garrouste, Cyril</creatorcontrib><creatorcontrib>Kamar, Nassim</creatorcontrib><creatorcontrib>Saune, Karine</creatorcontrib><creatorcontrib>Abravanel, Florence</creatorcontrib><creatorcontrib>Mansuy, Jean-Michel</creatorcontrib><creatorcontrib>Dubois, Martine</creatorcontrib><creatorcontrib>Rostaing, Lionel</creatorcontrib><creatorcontrib>Izopet, Jacques</creatorcontrib><title>Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients</title><title>The Journal of Infectious Diseases</title><addtitle>J Infect Dis</addtitle><description>Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solidorgan transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Entropy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Heterogeneity</subject><subject>Genotypes</subject><subject>Hepatitis E</subject><subject>Hepatitis E - immunology</subject><subject>Hepatitis E - virology</subject><subject>Hepatitis E virus</subject><subject>Hepatitis E virus - genetics</subject><subject>Hepatitis E virus - immunology</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunocompromised Host</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Organ Transplantation - adverse effects</subject><subject>PARASITES</subject><subject>Peptides - genetics</subject><subject>Peptides - immunology</subject><subject>Polymerase chain reaction</subject><subject>RNA</subject><subject>Transplantation</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - immunology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><recordid>eNqFks1rFDEYxoModq0ePSoBEbyMzcfk6yJIW7sLFRdRryHNZNYsM8k2yVj2vzd11kW9eArJ-8vz5nmfAPAco7cYKXrmQ9_5fLb1paXyAVhgRkXDOaYPwQIhQhoslToBT3LeIoRaysVjcEKo4i3GeAHuVqEfJhesg7GH6zjsdykOPjj42W18DNCEDn40NkV4EUfjA7xywRVv4dIVl-Km7nzZw0ouL7_BtUvZ5_JLr7KrcZxCtHGsoqPProNrU7wLJT8Fj3ozZPfssJ6Crx8uv5wvm-tPV6vz99eNZZyXhhgimWGO3BghpOKcMElIpxhXylgsSYeFwJIJYdu-t63qKDOmnlDX9tQyegrezbq76WZ0na29kxn0LvnRpL2Oxuu_K8F_15v4QwuMBEX3Am8OAineTi4XXY1YNwwmuDhljbkUXFKC1f_RViHBiMKooq_-QbdxSqFOQpMWcUIxV6RSzUzV8eecXH98N0b6Pn09p6_n9Cv_8k-zR_p33BV4fQBMtmbokwm2Xj9ykmJVzVTuxcxtc4npWG-pQELVv_UTp0HEWg</recordid><startdate>20140115</startdate><enddate>20140115</enddate><creator>Lhomme, Sebastien</creator><creator>Garrouste, Cyril</creator><creator>Kamar, Nassim</creator><creator>Saune, Karine</creator><creator>Abravanel, Florence</creator><creator>Mansuy, Jean-Michel</creator><creator>Dubois, Martine</creator><creator>Rostaing, Lionel</creator><creator>Izopet, Jacques</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>COVID</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20140115</creationdate><title>Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients</title><author>Lhomme, Sebastien ; Garrouste, Cyril ; Kamar, Nassim ; Saune, Karine ; Abravanel, Florence ; Mansuy, Jean-Michel ; Dubois, Martine ; Rostaing, Lionel ; Izopet, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-2a285a5e2ba77896625822d95699ac182d17718577c4ffc49d35aa7183e4f3c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Entropy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Heterogeneity</topic><topic>Genotypes</topic><topic>Hepatitis E</topic><topic>Hepatitis E - immunology</topic><topic>Hepatitis E - virology</topic><topic>Hepatitis E virus</topic><topic>Hepatitis E virus - genetics</topic><topic>Hepatitis E virus - immunology</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunocompromised Host</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Organ Transplantation - adverse effects</topic><topic>PARASITES</topic><topic>Peptides - genetics</topic><topic>Peptides - immunology</topic><topic>Polymerase chain reaction</topic><topic>RNA</topic><topic>Transplantation</topic><topic>Viral Proteins - genetics</topic><topic>Viral Proteins - immunology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lhomme, Sebastien</creatorcontrib><creatorcontrib>Garrouste, Cyril</creatorcontrib><creatorcontrib>Kamar, Nassim</creatorcontrib><creatorcontrib>Saune, Karine</creatorcontrib><creatorcontrib>Abravanel, Florence</creatorcontrib><creatorcontrib>Mansuy, Jean-Michel</creatorcontrib><creatorcontrib>Dubois, Martine</creatorcontrib><creatorcontrib>Rostaing, Lionel</creatorcontrib><creatorcontrib>Izopet, Jacques</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Coronavirus Research Database</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lhomme, Sebastien</au><au>Garrouste, Cyril</au><au>Kamar, Nassim</au><au>Saune, Karine</au><au>Abravanel, Florence</au><au>Mansuy, Jean-Michel</au><au>Dubois, Martine</au><au>Rostaing, Lionel</au><au>Izopet, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients</atitle><jtitle>The Journal of Infectious Diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2014-01-15</date><risdate>2014</risdate><volume>209</volume><issue>2</issue><spage>300</spage><epage>303</epage><pages>300-303</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Hepatitis E virus (HEV) can chronically infect immunocompromised patients. The polyproline region (PPR) and the macro domain of ORF1 protein may modulate virus production and/or the host immune response. We investigated the association between the genetic heterogeneity of HEV quasispecies in ORF1 and the outcome of infection in solidorgan transplant patients. Both sequence entropy and genetic distances during the hepatitis E acute phase were higher in patients whose infection became chronic than in those who cleared the virus. Hence, great quasispecies heterogeneity in the regions encoding the PPR and the macro domain may facilitate HEV persistence.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>23964111</pmid><doi>10.1093/infdis/jit438</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of Infectious Diseases, 2014-01, Vol.209 (2), p.300-303 |
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| language | eng |
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| source | Coronavirus Research Database |
| subjects | Adult Biological and medical sciences Chronic Disease Entropy Female Fundamental and applied biological sciences. Psychology Genetic Heterogeneity Genotypes Hepatitis E Hepatitis E - immunology Hepatitis E - virology Hepatitis E virus Hepatitis E virus - genetics Hepatitis E virus - immunology Humans Immune response Immunocompromised Host Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Middle Aged Organ Transplantation - adverse effects PARASITES Peptides - genetics Peptides - immunology Polymerase chain reaction RNA Transplantation Viral Proteins - genetics Viral Proteins - immunology Viruses |
| title | Influence of Polyproline Region and Macro Domain Genetic Heterogeneity on HEV Persistence in Immunocompromised Patients |
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