FinnTwin12 Cohort: An Updated Review

This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983-1987 along wit...

Full description

Saved in:
Bibliographic Details
Published in:Twin research and human genetics 2019-10, Vol.22 (5), p.302-311
Main Authors: Rose, Richard J, Salvatore, Jessica E, Aaltonen, Sari, Barr, Peter B, Bogl, Leonie H, Byers, Holly A, Heikkilä, Kauko, Korhonen, Tellervo, Latvala, Antti, Palviainen, Teemu, Ranjit, Anu, Whipp, Alyce M, Pulkkinen, Lea, Dick, Danielle M, Kaprio, Jaakko
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Female
Finland
Follow-Up Studies
Gene-Environment Interaction
Humans
Male
Substance-Related Disorders - genetics
Twins - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983-1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene-environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.
ISSN:1832-4274
1839-2628
DOI:10.1017/thg.2019.83