Effect of Viral Infections on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Diseases

The effect of 100 separate viral infections of the respiratory tract on pulmonary function was evaluated prospectively over an eight-year period in 84 patients with chronic obstructive pulmonary diseases and in eight normal subjects. Some viral infections were associated with small acute declines in...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 1980-03, Vol.141 (3), p.271-280
Main Authors: Smith, Charles B., Kanner, Richard E., Golden, Carole A., Klauber, Melville R., Renzetti, Attilio D.
Format: Article
Language:English
Subjects:
Acute Disease
Adverse effects
Chronic bronchitis
Chronic obstructive pulmonary disease
Diseases
Forced Expiratory Volume
Haemophilus influenzae - isolation & purification
Humans
Infections
Infectious Diseases
Influenza, Human - complications
Influenza, Human - etiology
Lung - physiopathology
Lung diseases
Lung Diseases, Obstructive - complications
Lung Volume Measurements
Mycoplasma Infections - complications
Mycoplasma pneumoniae - isolation & purification
Orthomyxoviridae - isolation & purification
Pulmonary functions
Viral infections
Virus Diseases - complications
Virus Diseases - etiology
Viruses
Vital Capacity
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Summary:The effect of 100 separate viral infections of the respiratory tract on pulmonary function was evaluated prospectively over an eight-year period in 84 patients with chronic obstructive pulmonary diseases and in eight normal subjects. Some viral infections were associated with small acute declines in forced vital capacity and/or 1-sec forced expiratory volume of 25–300 ml. These declines were detectable only during the 90-day period after infection. The greatest abnormalities of pulmonary function followed infections with influenza virus, and the mean acute changes in I-sec forced expiratory volume (- 118.5 ml) were significantly greater than expected (- 15.2 ml; P = 0.03). Smaller, statistically insignificant declines followed infections with parainfluenza virus, rhinovirus, adenovirus, and respiratory syncytial virus, and no changes were detectable after infections with coronavirus, herpes simplex virus, Mycoplasma pneumoniae, and Haemophilus influenzae. Long-term effects of influenza or other viral infections on the course of chronic obstructive pulmonary disease were not detected in this study population.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/141.3.271