Human Torovirus: A New Nosocomial Gastrointestinal Pathogen

Studies were undertaken to determine if human torovirus is associated with gastroenteritis and to examine the clinical features of torovirus illness in children. The fecal excretion of torovirus in patients with gastroenteritis was compared with that in matched asymptomatic controls in a case-contro...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 1998-11, Vol.178 (5), p.1263-1269
Main Authors: Jamieson, Frances B., Wang, Elaine E. L., Bain, Cindy, Good, Jennifer, Duckmanton, Lynn, Petric, Martin
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Case-Control Studies
Child
Child health services
Child, Preschool
Cross Infection - virology
Diarrhea
Feces - virology
Female
Gastroenteritis
Gastroenteritis - virology
Human viral diseases
Humans
Immunocompromised populations
Infant
Infections
Infectious diseases
Major
Male
Mamastrovirus - isolation & purification
Medical sciences
Microscopy, Electron
Pathogens
Rotavirus
Rotavirus - isolation & purification
Specimens
Torovirus
Torovirus - isolation & purification
Torovirus Infections - virology
Viral diseases
Viral diseases of the digestive system
Virus Shedding
Viruses
Citations: Items that cite this one
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Description
Summary:Studies were undertaken to determine if human torovirus is associated with gastroenteritis and to examine the clinical features of torovirus illness in children. The fecal excretion of torovirus in patients with gastroenteritis was compared with that in matched asymptomatic controls in a case-control study. Toroviruses were identified in 72 (35.0%) of 206 gastroenteritis cases compared with 30 (14.5%) of 206 controls (P < .001). Clinical features of torovirus gastroenteritis in 172 patients positive for torovirus were compared with those of 115 patients infected with rotavirus or astrovirus. Persons infected with torovirus were more frequently immunocompromised (43.0% vs. 15.7%) and nosocomially infected (57.6% vs. 31.3%). They also experienced less vomiting (46.4% vs. 66.7%) but had more bloody diarrhea (11.2% vs. 1.8%). An antibody response to torovirus developed mainly in older, nonimmunocompromised children (P < .01). These studies demonstrate an association between torovirus excretion and gastroenteritis in the pediatric population among immunocompromised hospitalized patients and in previously healthy patients.
ISSN:0022-1899
1537-6613
DOI:10.1086/314434