Viral epidemiology of acute exacerbations of chronic obstructive pulmonary disease

Abstract The role of viruses in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) needs further elucidation. The aim of the present study was to evaluate the molecular epidemiology of viral pathogens in AECOPD. Patients presenting to the Emergency Room with AECOPD needing hospita...

Full description

Saved in:
Bibliographic Details
Published in:Pulmonary pharmacology & therapeutics 2012-02, Vol.25 (1), p.12-18
Main Authors: Dimopoulos, G, Lerikou, M, Tsiodras, S, Chranioti, Aik, Perros, E, Anagnostopoulou, U, Armaganidis, A, Karakitsos, P
Format: Article
Language:English
Subjects:
Aged
Blood Gas Analysis
Coinfection
Comorbidity
Cough - etiology
Dyspnea - etiology
Emergency Medical Services - statistics & numerical data
Female
Hospitalization
Humans
Leukocyte Count
Male
Medical Education
Microarray Analysis
Middle Aged
Molecular Epidemiology
Oropharynx - virology
Polymerase Chain Reaction - methods
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - virology
Pulmonary/Respiratory
Respiratory Function Tests
Spirometry
Sputum - virology
Survival
Treatment Outcome
Viral Proteins - analysis
Viral Proteins - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The role of viruses in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) needs further elucidation. The aim of the present study was to evaluate the molecular epidemiology of viral pathogens in AECOPD. Patients presenting to the Emergency Room with AECOPD needing hospitalization were recruited. Oropharyngeal and sputum samples were collected in order to perform microarrays-based viral testing for the detection of respiratory viruses. A total of 200 (100%) patients were analyzed and from them in 107 (53.5%) a virus was detected. The commonest identified viruses were the human Respiratory Syncytial Virus (subtypes A and B) (40.5%), influenza virus (subtypes A, B, C) (11%), rhinovirus (8%) and human Parainfluenza Virus (subtypes A and B) (7.5%). A bacterial pathogen was isolated in 27 (14%) patients and a dual infection due to a bacterial and a viral pathogen was recognised in 14/107 patients. Patients with AECOPD and a viral infection had a lengthier hospital stay (9.2 ± 4.6 vs 7.6 ± 4.3, p  
ISSN:1094-5539
1522-9629
DOI:10.1016/j.pupt.2011.08.004