Continuous Albuterol With Benzalkonium in Children Hospitalized With Severe Asthma

The albuterol dropper bottle used to prepare solutions for continuous nebulization contains the preservative benzalkonium chloride (BAC). BAC, by itself, has been shown to cause bronchospasm. We hypothesized that BAC would decrease the therapeutic efficacy of albuterol in patients with acute asthma...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2020-04, Vol.145 (4), p.1
Main Authors: Pertzborn, Matthew C, Prabhakaran, Sreekala, Abu-Hasan, Mutasim, Baker, Dawn, Wu, Samuel, Wu, Yue, Hendeles, Leslie
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Albuterol - administration & dosage
Albuterol - antagonists & inhibitors
Albuterol - chemistry
Asthma
Asthma - drug therapy
Benzalkonium chloride
Benzalkonium Compounds - administration & dosage
Benzalkonium Compounds - adverse effects
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - antagonists & inhibitors
Bronchodilator Agents - chemistry
Bronchospasm
Child
Child, Preschool
Confidence intervals
Disease Progression
Drug Interactions
Female
Humans
Infant
Infant, Newborn
Kaplan-Meier Estimate
Linear Models
Male
Patients
Pediatrics
Preservatives
Preservatives, Pharmaceutical - administration & dosage
Preservatives, Pharmaceutical - adverse effects
Regression Analysis
Retrospective Studies
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Summary:The albuterol dropper bottle used to prepare solutions for continuous nebulization contains the preservative benzalkonium chloride (BAC). BAC, by itself, has been shown to cause bronchospasm. We hypothesized that BAC would decrease the therapeutic efficacy of albuterol in patients with acute asthma exacerbations. We performed a retrospective cohort study comparing the clinical outcomes of patients
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2019-0107