A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides

A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N-phenylacetamides was developed. Notably, th...

Full description

Saved in:
Bibliographic Details
Published in:Tetrahedron letters 2013-02, Vol.54 (6), p.576-578
Main Authors: Novikov, Mikhail S., Babkov, Denis A., Paramonova, Maria P., Chizhov, Alexander O., Khandazhinskaya, Anastasia L., Seley-Radtke, Katherine L.
Format: Article
Language:English
Subjects:
Heteroaromatic
Heterocycles
NNRTI
Pyrimidines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N-phenylacetamides was developed. Notably, the new route avoids the intractable workups and byproducts previously reported procedures have been associated with, thereby making this approach highly attractive to adaptation with other heterocyclics.
ISSN:0040-4039
1873-3581
0040-4039
DOI:10.1016/j.tetlet.2012.11.090