A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides

A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N-phenylacetamides was developed. Notably, th...

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Published in:Tetrahedron letters 2013-02, Vol.54 (6), p.576-578
Main Authors: Novikov, Mikhail S., Babkov, Denis A., Paramonova, Maria P., Chizhov, Alexander O., Khandazhinskaya, Anastasia L., Seley-Radtke, Katherine L.
Format: Article
Language:English
Subjects:
Heteroaromatic
Heterocycles
NNRTI
Pyrimidines
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cited_by cdi_FETCH-LOGICAL-c463t-1712893f1e2e94414727b08813453fa082d8bb252ddf2c6224af2edd8b5ca5163
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container_issue 6
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container_title Tetrahedron letters
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creator Novikov, Mikhail S.
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description A series of heterocyclic compounds were designed as potential nonnucleoside HIV reverse transcriptase inhibitors. Although the compounds ultimately proved inactive against HIV, during the course of the synthesis, a new and highly facile method to realize N-phenylacetamides was developed. Notably, the new route avoids the intractable workups and byproducts previously reported procedures have been associated with, thereby making this approach highly attractive to adaptation with other heterocyclics.
doi_str_mv 10.1016/j.tetlet.2012.11.090
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source ScienceDirect Journals
subjects Heteroaromatic
Heterocycles
NNRTI
Pyrimidines
title A highly facile approach to the synthesis of novel 2-(3-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-N-phenylacetamides
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