Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day

Physiological changes in humans are evident under environmental conditions similar to those on a Mars mission involving both a space factor (long-term isolation) and a time factor (the Mars solar day). However, very few studies have investigated the response of the liver to those conditions. Serum p...

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Published in:BioMed research international 2020, Vol.2020 (2020), p.1-7
Main Authors: Qu, Lina, Li, Yinghui, Xiong, Jianghui, Li, Kai, Liang, Fengji, Lu, Liang, Yuan, Yanhong, Ji, Guohua, Lv, Ke, Chen, Hailong, Xu, Zi
Format: Article
Language:English
Subjects:
Acclimatization
Adaptation, Physiological
Adult
Alkaline phosphatase
Alkaline Phosphatase - blood
Bilirubin
Bilirubin - blood
Biological response modifiers
Blood
Blood Proteins - metabolism
Cholesterol
Circadian rhythm
Controlled ecological life support systems
Cytokines
Earth Day
Environmental changes
Environmental conditions
Female
gamma-Glutamyltransferase - blood
Globulins
Globulins - metabolism
Homeostasis
Humans
Immunology
Interferon
Interferon-gamma - blood
Interleukin 6
Interleukin-6 - blood
Interleukins
Levels
Life Support Systems
Lipids
Lipoproteins
Liver
Liver - physiology
Male
Mars
Mars missions
Metabolism
Phosphatase
Phosphatases
Physiology
Proteins
Sleep
Space Flight
Transaminases - blood
Triglycerides
γ-Glutamyltransferase
γ-Interferon
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cited_by cdi_FETCH-LOGICAL-c499t-62c019cff57d4f9a76a0bfac54a065d16b79ddd11e43c42d22a847653fff3b3f3
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container_issue 2020
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container_title BioMed research international
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creator Qu, Lina
Li, Yinghui
Xiong, Jianghui
Li, Kai
Liang, Fengji
Lu, Liang
Yuan, Yanhong
Ji, Guohua
Lv, Ke
Chen, Hailong
Xu, Zi
description Physiological changes in humans are evident under environmental conditions similar to those on a Mars mission involving both a space factor (long-term isolation) and a time factor (the Mars solar day). However, very few studies have investigated the response of the liver to those conditions. Serum protein levels, bilirubin levels, aminotransferase activities, blood alkaline phosphatase, gamma-glutamyltransferase, lipid levels, and serum cytokines interleukin-6 and interferon-γ levels were analyzed 30 days before the mock mission; on days 2, 30, 60, 75, 90, 105, 120, 150, and 175 of the mission; and 30 days after the mission, in four subjects in 4-person 180-day Controlled Ecological Life Support System Experiment. Serum protein levels (total protein and globulin) decreased and bilirubin increased under the isolation environment from day 2 and exhibited chronic acclimatization from days 30 to 175. Effects of the Mars solar day were evident on day 75. Blood lipid levels were somewhat affected. No obvious peak in any enzyme level was detected during the mission. The change tendency of these results indicated that future studies should explore whether protein parameters especially globulin could serve as indicators of immunological function exposure to the stress of a Mars mission.
doi_str_mv 10.1155/2020/2796510
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source Wiley-Blackwell Open Access Collection; Publicly Available Content Database
subjects Acclimatization
Adaptation, Physiological
Adult
Alkaline phosphatase
Alkaline Phosphatase - blood
Bilirubin
Bilirubin - blood
Biological response modifiers
Blood
Blood Proteins - metabolism
Cholesterol
Circadian rhythm
Controlled ecological life support systems
Cytokines
Earth Day
Environmental changes
Environmental conditions
Female
gamma-Glutamyltransferase - blood
Globulins
Globulins - metabolism
Homeostasis
Humans
Immunology
Interferon
Interferon-gamma - blood
Interleukin 6
Interleukin-6 - blood
Interleukins
Levels
Life Support Systems
Lipids
Lipoproteins
Liver
Liver - physiology
Male
Mars
Mars missions
Metabolism
Phosphatase
Phosphatases
Physiology
Proteins
Sleep
Space Flight
Transaminases - blood
Triglycerides
γ-Glutamyltransferase
γ-Interferon
title Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day
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