Development of Disseminated Tuberculosis with Intestinal Involvement due to Adalimumab Administration Despite Latent Tuberculosis Treatment

Treatment of latent tuberculosis infection (LTBI) reduces the probability of reactivation of tuberculosis associated with anti-tumor necrosis factor (TNF) α inhibitors, but no chemoprophylaxis is completely protective. We herein report a woman with rheumatoid arthritis who developed disseminated tub...

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Bibliographic Details
Published in:Internal Medicine 2020/03/15, Vol.59(6), pp.849-853
Main Authors: Ikuta, Kozo, Ota, Yumiko, Kuroki, Shigenobu, Matsumoto, Yoshihide, Senda, Eri, Mukohara, Saki, Takahashi, Soshi, Monden, Kazuya, Fukuda, Akihisa, Seno, Hiroshi, Kumagai, Shunichi, Shio, Seiji
Format: Article
Language:English
Subjects:
anti-TNFα inhibitor
Case Report
disseminated tuberculosis
Internal medicine
intestinal tuberculosis
Intestine
latent tuberculosis infection
Monoclonal antibodies
Mucosa
reactivation of tuberculosis
Rheumatoid arthritis
Sputum
Tuberculosis
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:Treatment of latent tuberculosis infection (LTBI) reduces the probability of reactivation of tuberculosis associated with anti-tumor necrosis factor (TNF) α inhibitors, but no chemoprophylaxis is completely protective. We herein report a woman with rheumatoid arthritis who developed disseminated tuberculosis with intestinal involvement during adalimumab administration despite LTBI treatment. Tuberculosis reactivation was not detected in sputum or urine but was detected from the terminal ileal mucosa. Detection of intestinal tuberculosis is rare in patients being treated with anti-TNFα therapy after LTBI treatment. As anti-TNFα inhibitors have become more common, the rate of reactivation of tuberculosis, including intestinal tuberculosis, has increased in patients being treated for LTBI.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3295-19