Case Report: Multidrug-Resistant Mycobacterium leprae in a Case of Smear-Negative Relapse

The ongoing transmission of leprosy in India is worrisome, and emerging drug resistance may be one of the factors responsible for the continued transmission of leprosy in India. Emerging cases of multidrug-resistant pose a great threat to eradication of leprosy and must be addressed with utmost prio...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2020-04, Vol.102 (4), p.724-727
Main Authors: Kamat, Divya, Narang, Tarun, Ahuja, Madhvi, Lavania, Mallika, Dogra, Sunil
Format: Article
Language:English
Subjects:
Adult
Case reports
Drug resistance
Drug Resistance, Multiple, Bacterial
Histopathology
Humans
India - epidemiology
Leprostatic Agents - pharmacology
Leprostatic Agents - therapeutic use
Leprosy
Leprosy - drug therapy
Leprosy - epidemiology
Leprosy - microbiology
Male
Multidrug resistant organisms
Mycobacterium leprae - drug effects
Recurrence
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Summary:The ongoing transmission of leprosy in India is worrisome, and emerging drug resistance may be one of the factors responsible for the continued transmission of leprosy in India. Emerging cases of multidrug-resistant pose a great threat to eradication of leprosy and must be addressed with utmost priority. We report a case of multidrug-resistant in a case of relapse where slit skin smear (SSS) was negative and histopathology was inconclusive. Drug resistance studies in leprosy are undertaken only in smear-positive relapse cases, and detection of this type of multidrug resistance in a case with negative SSS and innocuous histopathology is rather unusual and highlights the importance of undertaking drug resistance tests even in smear-negative cases of leprosy relapse. Resistance to ofloxacin (OFL) is also a cause for concern as OFL is one of the reserve drugs recommended for treatment of rifampicin-resistant strains.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.19-0905