Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of oc...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-22
Main Authors: Zheng, Ya-juan, Niu, Ling-zhi, Li, Ke, Zhang, Hong, Zhao, Jing, Wang, Ming-xuan, Wang, Yuan-ping
Format: Article
Language:English
Subjects:
Air pollution
Antioxidants
Apoptosis
Cataract
Cell adhesion & migration
Deoxyribonucleic acid
Development and progression
Disease
DNA
DNA damage
Enzymes
Gene expression
Genetic research
Glaucoma
Health aspects
Ionizing radiation
Kinases
Medical research
Medicine, Experimental
Mitochondrial DNA
Mutation
Outdoor air quality
Oxidation
Oxidative stress
Prevention
Proteins
Review
Trimetazidine
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Summary:Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.
ISSN:1942-0900
1942-0994
DOI:10.1155/2020/9410952