Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells

• Published in: Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.219-232
• Main Authors: González, Florencia B, Villar, Silvina R, Fernández Bussy, Rodrigo, Martin, Gaëlle H, Pérol, Louis, Manarin, Romina, Spinelli, Silvana V, Pilon, Caroline, Cohen, José Laurent, Bottasso, Oscar A, Piaggio, Eliane, Pérez, Ana R
• Format: Article
• Language: English
• Subjects: Adrenalectomy; Allergy and Immunology; Animals; Chagas Cardiomyopathy - immunology; Chagas Cardiomyopathy - pathology; Chagas disease; Chagas Disease - immunology; Chagas Disease - pathology; Corticosterone - blood; Dexamethasone - pharmacology; Disease Models, Animal; GATA3 Transcription Factor - drug effects; GATA3 Transcription Factor - immunology; Glucocorticoids; Glucocorticoids - pharmacology; IFN-γ; IL-2; Interferon-gamma - drug effects; Interferon-gamma - immunology; Interleukin-10 - immunology; Interleukin-2 - pharmacology; Interleukin-4 - immunology; Mice; Mice, Inbred C57BL; Muscle, Skeletal - pathology; Myocardium - pathology; Phenotype; Psychiatry; Regulatory T cells; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; Th1 Cells - drug effects; Th1 Cells - immunology; Trypanosoma cruzi; Trypanosoma cruzi - immunology
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2014.11.016

Highlights • Treg/Teff cell balance is under endocrine control during T. cruzi infection. • During acute infection Treg cells acquire a pathogenic Th-1 like phenotype. • IL-2 plus dexamethasone combined treatment before infection increases Treg cell proportions.