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Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells
Highlights • Treg/Teff cell balance is under endocrine control during T. cruzi infection. • During acute infection Treg cells acquire a pathogenic Th-1 like phenotype. • IL-2 plus dexamethasone combined treatment before infection increases Treg cell proportions.
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| Published in: | Brain, behavior, and immunity behavior, and immunity, 2015-03, Vol.45, p.219-232 |
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| container_end_page | 232 |
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| container_title | Brain, behavior, and immunity |
| container_volume | 45 |
| creator | González, Florencia B Villar, Silvina R Fernández Bussy, Rodrigo Martin, Gaëlle H Pérol, Louis Manarin, Romina Spinelli, Silvana V Pilon, Caroline Cohen, José Laurent Bottasso, Oscar A Piaggio, Eliane Pérez, Ana R |
| description | Highlights • Treg/Teff cell balance is under endocrine control during T. cruzi infection. • During acute infection Treg cells acquire a pathogenic Th-1 like phenotype. • IL-2 plus dexamethasone combined treatment before infection increases Treg cell proportions. |
| doi_str_mv | 10.1016/j.bbi.2014.11.016 |
| format | article |
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All rights reserved. 2014 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-1bfc15374fa031221e2e488e42b45e065c42803e7f70493a435c0350c5ad4583</citedby><cites>FETCH-LOGICAL-c539t-1bfc15374fa031221e2e488e42b45e065c42803e7f70493a435c0350c5ad4583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25483139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González, Florencia B</creatorcontrib><creatorcontrib>Villar, Silvina R</creatorcontrib><creatorcontrib>Fernández Bussy, Rodrigo</creatorcontrib><creatorcontrib>Martin, Gaëlle H</creatorcontrib><creatorcontrib>Pérol, Louis</creatorcontrib><creatorcontrib>Manarin, Romina</creatorcontrib><creatorcontrib>Spinelli, Silvana V</creatorcontrib><creatorcontrib>Pilon, Caroline</creatorcontrib><creatorcontrib>Cohen, José Laurent</creatorcontrib><creatorcontrib>Bottasso, Oscar A</creatorcontrib><creatorcontrib>Piaggio, Eliane</creatorcontrib><creatorcontrib>Pérez, Ana R</creatorcontrib><title>Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>Highlights • Treg/Teff cell balance is under endocrine control during T. cruzi infection. • During acute infection Treg cells acquire a pathogenic Th-1 like phenotype. • IL-2 plus dexamethasone combined treatment before infection increases Treg cell proportions.</description><subject>Adrenalectomy</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Chagas Cardiomyopathy - 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| fulltext | fulltext |
| identifier | ISSN: 0889-1591 |
| ispartof | Brain, behavior, and immunity, 2015-03, Vol.45, p.219-232 |
| issn | 0889-1591 1090-2139 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7126853 |
| source | Elsevier |
| subjects | Adrenalectomy Allergy and Immunology Animals Chagas Cardiomyopathy - immunology Chagas Cardiomyopathy - pathology Chagas disease Chagas Disease - immunology Chagas Disease - pathology Corticosterone - blood Dexamethasone - pharmacology Disease Models, Animal GATA3 Transcription Factor - drug effects GATA3 Transcription Factor - immunology Glucocorticoids Glucocorticoids - pharmacology IFN-γ IL-2 Interferon-gamma - drug effects Interferon-gamma - immunology Interleukin-10 - immunology Interleukin-2 - pharmacology Interleukin-4 - immunology Mice Mice, Inbred C57BL Muscle, Skeletal - pathology Myocardium - pathology Phenotype Psychiatry Regulatory T cells T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - drug effects Th1 Cells - immunology Trypanosoma cruzi Trypanosoma cruzi - immunology |
| title | Immunoendocrine dysbalance during uncontrolled T. cruzi infection is associated with the acquisition of a Th-1-like phenotype by Foxp3+ T cells |
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