Equine arteritis virus

Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of c...

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Bibliographic Details
Published in:Veterinary microbiology 2013-11, Vol.167 (1-2), p.93-122
Main Authors: Balasuriya, Udeni B.R., Go, Yun Young, MacLachlan, N. James
Format: Article
Language:English
Subjects:
Animals
Arterivirus Infections - immunology
Arterivirus Infections - veterinary
Arterivirus Infections - virology
EAV
Equartevirus - genetics
Equartevirus - immunology
Equartevirus - physiology
Equine arteritis virus
EVA
Genome, Viral - genetics
Horse Diseases - immunology
Horse Diseases - virology
Horses
Host-Pathogen Interactions
Viral Proteins - genetics
Viral Proteins - metabolism
Virion - physiology
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Summary:Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2013.06.015